Let-7g Improves Multiple Endothelial Functions Through Targeting Transforming Growth Factor-Beta and SIRT-1 Signaling - Liao, Yi-Chu; Wang, Yung-Song; Guo, Yuh-Cherng; Lin, Wen-Lien; Chang, Ming-Hung; Juo, Suh-Hang Hank (Journal of the American College of Cardiology, 2014)
Keywords: Angiogenesis; Animals; Atherosclerosis; Biological and medical sciences; Cardiology; Cardiology. Vascular system; Cardiovascular; Cardiovascular disease; Cardiovascular Diseases - genetics; Cardiovascular Diseases - metabolism; Cardiovascular Diseases - physiopathology; Cell adhesion & migration; Coronary vessels; Disease Models, Animal; endothelial function; Endothelium; Endothelium, Vascular - metabolism; Endothelium, Vascular - pathology; Endothelium, Vascular - physiopathology; Experiments; Female; Gene Expression Regulation; Heart; Humans; Let-7g; Male; Medical sciences; Mice; Mice, Knockout; MicroRNAs - genetics; PAI-1; Plasmids; Polymerase Chain Reaction; Proteins; RNA - genetics; Senescence; Signal Transduction; SIRT-1; Sirtuin 1 - biosynthesis; Sirtuin 1 - genetics; Studies; TGF-β pathway; Transforming Growth Factor beta - biosynthesis; Transforming Growth Factor beta - genetics; Vasodilation - genetics; United States--US; California; endothelial function; SMAD2; IL; ADMA; THBS1; SIRT-1; VCAM; TGF-β pathway; TGF; Let-7g; PAI-1; HUVEC; miRNA; PAI; qPCR; MCP; EC; SIRT; human umbilical endothelial cell; microribonucleic acid; SMAD family member 2; sirtuin; interleukin; plasminogen activator inhibitor; quantitative real-time polymerase chain reaction; monocyte chemotactic protein; endothelial cell; asymmetric dimethyl arginine; vascular cell adhesion molecule; transforming growth factor; thrombospondin-1; Improvement; Multiple; Targeting; Transforming growth factor β; Cardiovascular disease; Circulatory system; Endothelial function; Cardiology