Gene-expression profile of the ageing brain in mice

• Published in: Nature genetics Vol. 25; no. 3; pp. 294 - 297
• Main Authors: Weindruch, Richard, Prolla, Tomas A, Lee, Cheol-Koo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 01.07.2000
• Subjects: Age; Aging; Aging - genetics; Alzheimer's disease; Animals; Biological and medical sciences; Brain; Brain - pathology; Brain - physiology; Brain research; Central nervous system; Cerebellum - pathology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dietary restrictions; Gene Expression; Genes; Genetic aspects; Health aspects; Inflammation; Male; Mammals; Medical sciences; Mice; Mice, Inbred C57BL; Neocortex - pathology; Nervous system diseases; Neurology; Oxidative stress; Parkinson's disease; Physiological aspects; Risk factors; RNA Stability; RNA, Messenger; Senescence; United States > US; Wisconsin; Animal model; Nervous system diseases; Alzheimer disease; Ageing; Rodentia; Central nervous system; Parkinson disease; Gene expression; Cerebral disorder; Vertebrata; Mammalia; Gene; Mouse; Central nervous system disease; Degenerative disease; Extrapyramidal syndrome; Brain (vertebrata)

Ageing of the brain leads to impairments in cognitive and motor skills, and is the major risk factor for several common neurological disorders such as Alzheimer disease (AD) and Parkinson disease (PD). Recent studies suggest that normal brain ageing is associated with subtle morphological and functi...