Dynamic changes in vasohibin and nitric oxide signaling following surgical resection of head and neck squamous cell carcinoma

• Published in: World journal of surgical oncology Vol. 23; no. 1; pp. 221 - 11
• Main Authors: Tai, Ying-Hsuan, Wu, Hsiang-Ling, Chu, You-Hsiang, Wu, Cheng-Hsien, Tai, Shyh-Kuan, Lin, Tso-Chou, Ho, Shung-Tai, Lu, Chih-Cherng
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07.06.2025; BioMed Central; BMC
• Subjects: Adult; Aged; Angiogenesis; Angiogenic Proteins; Biomarker; Biomarkers, Tumor - blood; Biomarkers, Tumor - metabolism; Care and treatment; Case-Control Studies; Cell Cycle Proteins - blood; Cell Cycle Proteins - metabolism; Cellular signal transduction; Female; Follow-Up Studies; Head and neck cancer; Head and Neck Neoplasms - blood; Head and Neck Neoplasms - metabolism; Head and Neck Neoplasms - pathology; Head and Neck Neoplasms - surgery; Health aspects; Humans; Leukocytes - metabolism; Male; Middle Aged; Neovascularization; Neovascularization, Pathologic - metabolism; Neovascularization, Pathologic - pathology; Nitric oxide; Nitric Oxide - blood; Nitric Oxide - metabolism; Nitric Oxide Synthase Type II - blood; Nitric Oxide Synthase Type II - metabolism; Phosphorylation; Prognosis; Prospective Studies; Proteases; Signal Transduction; Squamous cell carcinoma; Squamous Cell Carcinoma of Head and Neck - blood; Squamous Cell Carcinoma of Head and Neck - metabolism; Squamous Cell Carcinoma of Head and Neck - pathology; Squamous Cell Carcinoma of Head and Neck - surgery; Vasohibin; Taiwan; Angiogenesis; Head and neck cancer; Biomarker; Nitric oxide; Vasohibin

Angiogenesis is essential for tumor growth and metastasis, with various molecules, including vasohibin (VASH), nitric oxide (NO), and inducible nitric oxide synthase (iNOS), implicated in its regulation and potential prognostic value in oncology. However, their roles in modulating surgery-induced an...