Stress-Induced Changes in Cerebral Metabolites, Hippocampal Volume, and Cell Proliferation are Prevented by Antidepressant Treatment with Tianeptine

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 98; no. 22; pp. 12796 - 12801
• Main Authors: Czéh, Boldizsár, Michaelis, Thomas, Watanabe, Takashi, Frahm, Jens, de Biurrun, Gabriel, van Kampen, Marja, Bartolomucci, Alessandro, Fuchs, Eberhard
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 23.10.2001; National Acad Sciences; The National Academy of Sciences
• Subjects: Animals; Antidepressants; Antidepressive Agents, Tricyclic - therapeutic use; Behavioral neuroscience; Biological Sciences; Biology; Brain; Brain - drug effects; Brain - metabolism; Cell Division - drug effects; Cell growth; Cellular metabolism; Dentate gyrus; Depression - drug therapy; Depression - metabolism; Depression - pathology; Hippocampus; Hippocampus - drug effects; Hippocampus - pathology; Hypothalamo-Hypophyseal System - drug effects; Hypothalamo-Hypophyseal System - physiology; Male; Metabolites; Neurogenesis; Neurology; Neurons; Pituitary-Adrenal System - drug effects; Pituitary-Adrenal System - physiology; Stress; Stress, Psychological - drug therapy; Stress, Psychological - metabolism; Stress, Psychological - pathology; Thiazepines - therapeutic use; tianeptine; Tupaia; Tupaia belangeri

Stress-induced structural remodeling in the adult hippocampus, involving debranching and shortening of dendrites and suppression of neurogenesis, provides a cellular basis for understanding the impairment of neural plasticity in the human hippocampus in depressive illness. Accordingly, reversal of s...