Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer's disease brain

• Published in: Free radical biology & medicine Vol. 45; no. 6; pp. 813 - 819
• Main Authors: Shao, Changxing, Xiong, Shuling, Li, Guo-Min, Gu, Liya, Mao, Guogen, Markesbery, William R., Lovell, Mark A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.09.2008
• Subjects: 4-Hydroxynonenal; Alzheimer Disease - enzymology; Alzheimer's disease; Blotting, Western; Brain - enzymology; Cell Nucleus - enzymology; Cognition Disorders - enzymology; DNA Glycosylases - metabolism; Female; Humans; Immunoprecipitation; Lipid peroxidation; Male; Mild cognitive impairment; Mitochondria - enzymology; Oxoguanine glycosylase; Polymorphism, Single-Stranded Conformational; PBS; AD; 4-Hydroxynonenal; DTT; Mild cognitive impairment; FL; OGG1; Lipid peroxidation; PMI; BER; LAD; CER; SDS-PAGE; MCI; NC; ROS; TL; PL; NFT; Alzheimer's disease; HNE; Oxoguanine glycosylase; 8-OHdG

Eight-hydroxy-2′-deoxyguanosine (8-OHdG) is increased in the brain in late-stage Alzheimer's disease (LAD) and mild cognitive impairment (MCI). To determine if decreased base-excision repair contributes to these elevations, we measured oxoguanine glycosylase 1 (OGG1) protein and incision activi...