Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection

• Published in: Molecular psychiatry Vol. 12; no. 4; pp. 385 - 397
• Main Authors: Ruzicka, W B, Zhubi, A, Veldic, M, Grayson, D R, Costa, E, Guidotti, A
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2007; Nature Publishing Group
• Subjects: Adult; Adult and adolescent clinical studies; Behavioral Sciences; Biological and medical sciences; Biological Psychology; Bipolar disorder; Brain; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases - genetics; DNA (Cytosine-5-)-Methyltransferases - metabolism; DNA methylation; DNA methyltransferase; DNMT1 protein; Epigenesis, Genetic - physiology; Epigenetics; Female; gamma-Aminobutyric Acid - metabolism; Gene expression; Glutamate Decarboxylase - metabolism; Glutamic acid; Humans; Hybridization; Interneurons; Isoenzymes - metabolism; Lasers; Male; Medical sciences; Medicine; Medicine & Public Health; Mental disorders; Microdissection - methods; Middle Aged; Neurons; Neurons - metabolism; Neurons - pathology; Neurosciences; original-article; Patients; Pharmacotherapy; Polymerase chain reaction; Prefrontal cortex; Prefrontal Cortex - pathology; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Pyramidal cells; Reelin protein; Reverse Transcriptase Polymerase Chain Reaction - methods; Reverse transcription; RNA, Messenger - biosynthesis; Schizophrenia; Schizophrenia - etiology; Schizophrenia - genetics; Schizophrenia - pathology; γ-Aminobutyric acid; United States > US; Chicago Illinois; reelin; laser-assisted microdissection; DNMT1; GAD; schizophrenia; epigenetics; Human; Central nervous system; Schizophrenia; Prefrontal cortex; GAD67; Encephalon; Psychosis; Reelin; Epigenesis; Gabaergic neuron
• ISSN: 1359-4184; 1476-5578
• DOI: 10.1038/sj.mp.4001954

Among the most consistent results of studies of post-mortem brain tissue from schizophrenia patients (SZP) is the finding that in this disease, several genes expressed by GABAergic neurons are downregulated. This downregulation may be caused by hypermethylation of the relevant promoters in affected...