short peptide from frog skin accelerates diabetic wound healing

• Published in: The FEBS journal Vol. 281; no. 20; pp. 4633 - 4643
• Main Authors: Liu, Han, Duan, Zilei, Tang, Jing, Lv, Qiumin, Rong, Mingqiang, Lai, Ren
• Format: Journal Article
• Language: English
• Published: England Blackwell 01.10.2014; Blackwell Publishing Ltd
• Subjects: amino acid sequences; amphibian; Angiogenesis; angiogenic proteins; animal models; Animals; anti-inflammatory activity; anti‐inflammatory; Anura; Blotting, Western; Diabetes; Diabetes Mellitus, Experimental - drug therapy; Diabetes Mellitus, Experimental - physiopathology; diabetic wounds; Disease Models, Animal; drugs; Enzyme-Linked Immunosorbent Assay; Frogs; healing; Immunoenzyme Techniques; inflammation; Male; Mice; Mice, Inbred BALB C; Mice, Obese; Neovascularization, Physiologic - drug effects; Odorrana; Peptide Fragments - pharmacology; Peptides; Pharmacology; Skin - blood supply; Skin - injuries; Skin - metabolism; tissue repair; Wound Healing; anti-inflammatory; wound healing; amphibian; angiogenesis; diabetic wounds

Delayed wound healing will result in the development of chronic wounds in some diseases, such as diabetes. Amphibian skins possess excellent wound‐healing ability and represent a resource for prospective wound‐healing promoting compounds. A potential wound‐healing promoting peptide (CW49; amino acid...