short peptide from frog skin accelerates diabetic wound healing

Delayed wound healing will result in the development of chronic wounds in some diseases, such as diabetes. Amphibian skins possess excellent wound‐healing ability and represent a resource for prospective wound‐healing promoting compounds. A potential wound‐healing promoting peptide (CW49; amino acid...

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Bibliographic Details
Published inThe FEBS journal Vol. 281; no. 20; pp. 4633 - 4643
Main Authors Liu, Han, Duan, Zilei, Tang, Jing, Lv, Qiumin, Rong, Mingqiang, Lai, Ren
Format Journal Article
LanguageEnglish
Published England Blackwell 01.10.2014
Blackwell Publishing Ltd
Subjects
amino acid sequences
amphibian
Angiogenesis
angiogenic proteins
animal models
Animals
anti-inflammatory activity
anti‐inflammatory
Anura
Blotting, Western
Diabetes
Diabetes Mellitus, Experimental - drug therapy
Diabetes Mellitus, Experimental - physiopathology
diabetic wounds
Disease Models, Animal
drugs
Enzyme-Linked Immunosorbent Assay
Frogs
healing
Immunoenzyme Techniques
inflammation
Male
Mice
Mice, Inbred BALB C
Mice, Obese
Neovascularization, Physiologic - drug effects
Odorrana
Peptide Fragments - pharmacology
Peptides
Pharmacology
Skin - blood supply
Skin - injuries
Skin - metabolism
tissue repair
Wound Healing
anti-inflammatory
wound healing
amphibian
angiogenesis
diabetic wounds
Online AccessGet full text

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Abstract Delayed wound healing will result in the development of chronic wounds in some diseases, such as diabetes. Amphibian skins possess excellent wound‐healing ability and represent a resource for prospective wound‐healing promoting compounds. A potential wound‐healing promoting peptide (CW49; amino acid sequence APFRMGICTTN) was identified from the frog skin of Odorrana grahami. It promotes wound healing in a murine model with a full‐thickness dermal wound in both normal and diabetic animals. In addition to its strong angiogenic ability with respect to the upregulation of some angiogenic proteins, CW49 also showed a significant anti‐inflammatory effect in diabetic wounds, which was very important for healing chronic wounds. CW49 had little effect on re‐epithelialization, resulting in no significant effect on wound closure rate compared to a vehicle control. Altogether, this indicated that CW49 might accelerate diabetic wound healing by promoting angiogenesis and preventing any excessive inflammatory response. Considering its favorable traits as a small peptide that significantly promotes angiogenesis, CW49 might be an excellent candidate or template for the development of a drug for use in the treatment of diabetic wounds.
AbstractList Delayed wound healing will result in the development of chronic wounds in some diseases, such as diabetes. Amphibian skins possess excellent wound-healing ability and represent a resource for prospective wound-healing promoting compounds. A potential wound-healing promoting peptide (CW49; amino acid sequence APFRMGICTTN) was identified from the frog skin of Odorrana grahami. It promotes wound healing in a murine model with a full-thickness dermal wound in both normal and diabetic animals. In addition to its strong angiogenic ability with respect to the upregulation of some angiogenic proteins, CW49 also showed a significant anti-inflammatory effect in diabetic wounds, which was very important for healing chronic wounds. CW49 had little effect on re-epithelialization, resulting in no significant effect on wound closure rate compared to a vehicle control. Altogether, this indicated that CW49 might accelerate diabetic wound healing by promoting angiogenesis and preventing any excessive inflammatory response. Considering its favorable traits as a small peptide that significantly promotes angiogenesis, CW49 might be an excellent candidate or template for the development of a drug for use in the treatment of diabetic wounds. A wound-healing promoting peptide (CW49) was first characterized from the skin of Odorrana grahami, which showed good effects in both normal and diabetic animals with strong angiogenic ability and significant anti-inflammatory effect. CW49 will not only provide a template for the development of novel wound-healing agent, but also reveal the possible mechanism for excellent skin wound repair ability of amphibians.
Delayed wound healing will result in the development of chronic wounds in some diseases, such as diabetes. Amphibian skins possess excellent wound-healing ability and represent a resource for prospective wound-healing promoting compounds. A potential wound-healing promoting peptide (CW49; amino acid sequence APFRMGICTTN) was identified from the frog skin of Odorrana grahami. It promotes wound healing in a murine model with a full-thickness dermal wound in both normal and diabetic animals. In addition to its strong angiogenic ability with respect to the upregulation of some angiogenic proteins, CW49 also showed a significant anti-inflammatory effect in diabetic wounds, which was very important for healing chronic wounds. CW49 had little effect on re-epithelialization, resulting in no significant effect on wound closure rate compared to a vehicle control. Altogether, this indicated that CW49 might accelerate diabetic wound healing by promoting angiogenesis and preventing any excessive inflammatory response. Considering its favorable traits as a small peptide that significantly promotes angiogenesis, CW49 might be an excellent candidate or template for the development of a drug for use in the treatment of diabetic wounds.
Delayed wound healing will result in the development of chronic wounds in some diseases, such as diabetes. Amphibian skins possess excellent wound‐healing ability and represent a resource for prospective wound‐healing promoting compounds. A potential wound‐healing promoting peptide ( CW 49; amino acid sequence APFRMGICTTN ) was identified from the frog skin of Odorrana grahami . It promotes wound healing in a murine model with a full‐thickness dermal wound in both normal and diabetic animals. In addition to its strong angiogenic ability with respect to the upregulation of some angiogenic proteins, CW 49 also showed a significant anti‐inflammatory effect in diabetic wounds, which was very important for healing chronic wounds. CW 49 had little effect on re‐epithelialization, resulting in no significant effect on wound closure rate compared to a vehicle control. Altogether, this indicated that CW 49 might accelerate diabetic wound healing by promoting angiogenesis and preventing any excessive inflammatory response. Considering its favorable traits as a small peptide that significantly promotes angiogenesis, CW 49 might be an excellent candidate or template for the development of a drug for use in the treatment of diabetic wounds.
Delayed wound healing will result in the development of chronic wounds in some diseases, such as diabetes. Amphibian skins possess excellent wound‐healing ability and represent a resource for prospective wound‐healing promoting compounds. A potential wound‐healing promoting peptide (CW49; amino acid sequence APFRMGICTTN) was identified from the frog skin of Odorrana grahami. It promotes wound healing in a murine model with a full‐thickness dermal wound in both normal and diabetic animals. In addition to its strong angiogenic ability with respect to the upregulation of some angiogenic proteins, CW49 also showed a significant anti‐inflammatory effect in diabetic wounds, which was very important for healing chronic wounds. CW49 had little effect on re‐epithelialization, resulting in no significant effect on wound closure rate compared to a vehicle control. Altogether, this indicated that CW49 might accelerate diabetic wound healing by promoting angiogenesis and preventing any excessive inflammatory response. Considering its favorable traits as a small peptide that significantly promotes angiogenesis, CW49 might be an excellent candidate or template for the development of a drug for use in the treatment of diabetic wounds. A wound‐healing promoting peptide (CW49) was first characterized from the skin of Odorrana grahami, which showed good effects in both normal and diabetic animals with strong angiogenic ability and significant anti‐inflammatory effect. CW49 will not only provide a template for the development of novel wound‐healing agent, but also reveal the possible mechanism for excellent skin wound repair ability of amphibians.
Delayed wound healing will result in the development of chronic wounds in some diseases, such as diabetes. Amphibian skins possess excellent wound‐healing ability and represent a resource for prospective wound‐healing promoting compounds. A potential wound‐healing promoting peptide (CW49; amino acid sequence APFRMGICTTN) was identified from the frog skin of Odorrana grahami. It promotes wound healing in a murine model with a full‐thickness dermal wound in both normal and diabetic animals. In addition to its strong angiogenic ability with respect to the upregulation of some angiogenic proteins, CW49 also showed a significant anti‐inflammatory effect in diabetic wounds, which was very important for healing chronic wounds. CW49 had little effect on re‐epithelialization, resulting in no significant effect on wound closure rate compared to a vehicle control. Altogether, this indicated that CW49 might accelerate diabetic wound healing by promoting angiogenesis and preventing any excessive inflammatory response. Considering its favorable traits as a small peptide that significantly promotes angiogenesis, CW49 might be an excellent candidate or template for the development of a drug for use in the treatment of diabetic wounds.
Author Lv, Qiumin
Liu, Han
Rong, Mingqiang
Duan, Zilei
Lai, Ren
Tang, Jing
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Keywords anti-inflammatory
wound healing
amphibian
angiogenesis
diabetic wounds
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Snippet Delayed wound healing will result in the development of chronic wounds in some diseases, such as diabetes. Amphibian skins possess excellent wound‐healing...
Delayed wound healing will result in the development of chronic wounds in some diseases, such as diabetes. Amphibian skins possess excellent wound-healing...
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StartPage 4633
SubjectTerms amino acid sequences
amphibian
Angiogenesis
angiogenic proteins
animal models
Animals
anti-inflammatory activity
anti‐inflammatory
Anura
Blotting, Western
Diabetes
Diabetes Mellitus, Experimental - drug therapy
Diabetes Mellitus, Experimental - physiopathology
diabetic wounds
Disease Models, Animal
drugs
Enzyme-Linked Immunosorbent Assay
Frogs
healing
Immunoenzyme Techniques
inflammation
Male
Mice
Mice, Inbred BALB C
Mice, Obese
Neovascularization, Physiologic - drug effects
Odorrana
Peptide Fragments - pharmacology
Peptides
Pharmacology
Skin - blood supply
Skin - injuries
Skin - metabolism
tissue repair
Wound Healing
Title short peptide from frog skin accelerates diabetic wound healing
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Ffebs.12968
https://www.ncbi.nlm.nih.gov/pubmed/25117795
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https://search.proquest.com/docview/1727687391
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