STING directly recruits WIPI2 for autophagosome formation during STING‐induced autophagy

• Published in: The EMBO journal Vol. 42; no. 8; pp. e112387 - n/a
• Main Authors: Wan, Wei, Qian, Chuying, Wang, Qian, Li, Jin, Zhang, Hongtao, Wang, Lei, Pu, Maomao, Huang, Yewei, He, Zhengfu, Zhou, Tianhua, Shen, Han‐Ming, Liu, Wei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.04.2023; Springer Nature B.V; John Wiley and Sons Inc
• Subjects: Attenuation; Autophagosomes - metabolism; Autophagy; Autophagy - physiology; Binding; cGAS; Clearances; cytoplasmic DNA; Deoxyribonucleic acid; DNA; DNA - metabolism; EMBO07; EMBO19; Humans; Life Sciences; Membrane Proteins - genetics; Membrane Proteins - metabolism; Nucleotidyltransferases - metabolism; Signal transduction; Signaling; STING; Vesicles; WIPI2; cGAS; STING; autophagy; WIPI2; cytoplasmic DNA

The cGAS‐STING pathway plays an important role in host defense by sensing pathogen DNA, inducing type I IFNs, and initiating autophagy. However, the molecular mechanism of autophagosome formation in cGAS‐STING pathway‐induced autophagy is still unclear. Here, we report that STING directly interacts...