Sleep and Parkinson's disease: A review of case-control polysomnography studies

• Published in: Movement disorders Vol. 27; no. 14; pp. 1729 - 1737
• Main Authors: Peeraully, Tasneem, Yong, Ming-Hui, Chokroverty, Sudhansu, Tan, Eng-King
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.12.2012; Wiley; Wiley Subscription Services, Inc
• Subjects: Biological and medical sciences; Case-Control Studies; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Humans; Medical sciences; Movement disorders; Neurology; obstructive sleep apnea; Parkinson Disease - complications; Parkinson Disease - physiopathology; Parkinson's; periodic leg movements; polysomnography; Polysomnography - methods; REM behavior disorder; sleep; Sleep - physiology; Sleep Wake Disorders - etiology; Sleep Wake Disorders - physiopathology; obstructive sleep apnea; Parkinson's; Nervous system diseases; Sleep apnea syndrome; periodic leg movements; Respiratory disease; Parkinson disease; Case control study; Polysomnography; Cerebral disorder; REM behavior disorder; Sleep; Central nervous system disease; Degenerative disease; Sleep wake cycle; Behavior; Extrapyramidal syndrome
• ISSN: 0885-3185; 1531-8257
• DOI: 10.1002/mds.25197

The link between Parkinson's disease (PD) and certain primary sleep disorders has yet to be clarified. We performed a systematic review of case‐control polysomnography studies to evaluate the relationship between PD and sleep disorders. A PubMed literature search and bibliography review yielded 15 case‐control polysomnography studies in patients with PD. Studies differed by recruitment methods, duration of polysomnography monitoring, and sleep parameters measured. Subjective sleepiness was greater in patients than controls (50%–66% vs 2.9%–12%) despite lack of objective increase in daytime sleepiness by mean sleep latency testing. The 4 case‐control polysomnography studies investigating rapid eye movement behavior disorder support a higher prevalence in PD (0%–47% vs 0%–1.8% in controls), although differences in diagnostic criteria hamper interpretation. The preponderance of evidence did not support an increased incidence of obstructive sleep apnea (27%–60% vs 13%–65%) or periodic leg movements of sleep in patients compared to controls. Adequately powered, prospective studies with uniform methodology and healthy controls are needed to further address the association and pathophysiological significance between PD and sleep problems. © 2012 Movement Disorder Society