Genetic modifiers of cardiorespiratory fitness response to lifestyle intervention

• Published in: Medicine and science in sports and exercise Vol. 46; no. 2; p. 302
• Main Authors: Peter, Inga, Papandonatos, George D, Belalcazar, L Maria, Yang, Yao, Erar, Bahar, Jakicic, John M, Unick, Jessica L, Balasubramanyam, Ashok, Lipkin, Edward W, Delahanty, Linda M, Wagenknecht, Lynne E, Wing, Rena R, McCaffery, Jeanne M, Huggins, Gordon S
• Format: Journal Article
• Language: English
• Published: United States 01.02.2014
• Subjects: Adrenergic beta-Antagonists - therapeutic use; Aged; Alleles; Calcium-Binding Proteins - genetics; Core Binding Factor Alpha 2 Subunit - genetics; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - physiopathology; Diabetes Mellitus, Type 2 - therapy; Exercise Test; Female; Health Behavior; Heterozygote; Humans; Life Style; Linkage Disequilibrium; Male; Metabolic Equivalent; Middle Aged; Obesity - genetics; Obesity - physiopathology; Obesity - therapy; Physical Exertion - physiology; Physical Fitness; Polymorphism, Single Nucleotide; Risk Reduction Behavior; Tacrolimus Binding Proteins - genetics

Numerous prospective studies indicate that improved cardiorespiratory fitness reduces type 2 diabetes risk and delays disease progression. We hypothesized that genetic variants modify fitness response to an intensive lifestyle intervention (ILI) in the Action for Health in Diabetes (Look AHEAD) rand...