Consumption of Hibiscus sabdariffa L. aqueous extract and its impact on systemic antioxidant potential in healthy subjects
BACKGROUND: To evaluate health benefits attributed to Hibiscus sabdariffa L. a randomized, open‐label, two‐way crossover study was undertaken to compare the impact of an aqueous H. sabdariffa L. extract (HSE) on the systemic antioxidant potential (AOP; assayed by ferric reducing antioxidant power (F...
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| Published in | Journal of the science of food and agriculture Vol. 92; no. 10; pp. 2207 - 2218 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Chichester, UK
John Wiley & Sons, Ltd
15.08.2012
Wiley John Wiley and Sons, Limited |
| Subjects | |
| Online Access | Get full text |
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| Abstract | BACKGROUND: To evaluate health benefits attributed to Hibiscus sabdariffa L. a randomized, open‐label, two‐way crossover study was undertaken to compare the impact of an aqueous H. sabdariffa L. extract (HSE) on the systemic antioxidant potential (AOP; assayed by ferric reducing antioxidant power (FRAP)) with a reference treatment (water) in eight healthy volunteers. The biokinetic variables were the areas under the curve (AUC) of plasma FRAP, ascorbic acid and urate that are above the pre‐dose concentration, and the amounts excreted into urine within 24 h (Ae0–24) of antioxidants as assayed by FRAP, ascorbic acid, uric acid, malondialdehyde (biomarker for oxidative stress), and hippuric acid (metabolite and potential biomarker for total polyphenol intake).
RESULTS: HSE caused significantly higher plasma AUC of FRAP, an increase in Ae0–24 of FRAP, ascorbic acid and hippuric acid, whereas malondialdehyde excretion was reduced. Furthermore, the main hibiscus anthocyanins as well as one glucuronide conjugate could be quantified in the volunteers' urine (0.02% of the administered dose).
CONCLUSION: The aqueous HSE investigated in this study enhanced the systemic AOP and reduced the oxidative stress in humans. Furthermore, the increased urinary hippuric acid excretion after HSE consumption indicates a high biotransformation of the ingested HSE polyphenols, most likely caused by the colonic microbiota. Copyright © 2012 Society of Chemical Industry |
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| AbstractList | To evaluate health benefits attributed to Hibiscus sabdariffa L. a randomized, open-label, two-way crossover study was undertaken to compare the impact of an aqueous H. sabdariffa L. extract (HSE) on the systemic antioxidant potential (AOP; assayed by ferric reducing antioxidant power (FRAP)) with a reference treatment (water) in eight healthy volunteers. The biokinetic variables were the areas under the curve (AUC) of plasma FRAP, ascorbic acid and urate that are above the pre-dose concentration, and the amounts excreted into urine within 24 h (Ae(0-24) ) of antioxidants as assayed by FRAP, ascorbic acid, uric acid, malondialdehyde (biomarker for oxidative stress), and hippuric acid (metabolite and potential biomarker for total polyphenol intake).BACKGROUNDTo evaluate health benefits attributed to Hibiscus sabdariffa L. a randomized, open-label, two-way crossover study was undertaken to compare the impact of an aqueous H. sabdariffa L. extract (HSE) on the systemic antioxidant potential (AOP; assayed by ferric reducing antioxidant power (FRAP)) with a reference treatment (water) in eight healthy volunteers. The biokinetic variables were the areas under the curve (AUC) of plasma FRAP, ascorbic acid and urate that are above the pre-dose concentration, and the amounts excreted into urine within 24 h (Ae(0-24) ) of antioxidants as assayed by FRAP, ascorbic acid, uric acid, malondialdehyde (biomarker for oxidative stress), and hippuric acid (metabolite and potential biomarker for total polyphenol intake).HSE caused significantly higher plasma AUC of FRAP, an increase in Ae(0-24) of FRAP, ascorbic acid and hippuric acid, whereas malondialdehyde excretion was reduced. Furthermore, the main hibiscus anthocyanins as well as one glucuronide conjugate could be quantified in the volunteers' urine (0.02% of the administered dose).RESULTSHSE caused significantly higher plasma AUC of FRAP, an increase in Ae(0-24) of FRAP, ascorbic acid and hippuric acid, whereas malondialdehyde excretion was reduced. Furthermore, the main hibiscus anthocyanins as well as one glucuronide conjugate could be quantified in the volunteers' urine (0.02% of the administered dose).The aqueous HSE investigated in this study enhanced the systemic AOP and reduced the oxidative stress in humans. Furthermore, the increased urinary hippuric acid excretion after HSE consumption indicates a high biotransformation of the ingested HSE polyphenols, most likely caused by the colonic microbiota.CONCLUSIONThe aqueous HSE investigated in this study enhanced the systemic AOP and reduced the oxidative stress in humans. Furthermore, the increased urinary hippuric acid excretion after HSE consumption indicates a high biotransformation of the ingested HSE polyphenols, most likely caused by the colonic microbiota. To evaluate health benefits attributed to Hibiscus sabdariffa L. a randomized, open-label, two-way crossover study was undertaken to compare the impact of an aqueous H. sabdariffa L. extract (HSE) on the systemic antioxidant potential (AOP; assayed by ferric reducing antioxidant power (FRAP)) with a reference treatment (water) in eight healthy volunteers. The biokinetic variables were the areas under the curve (AUC) of plasma FRAP, ascorbic acid and urate that are above the pre-dose concentration, and the amounts excreted into urine within 24 h (...) of antioxidants as assayed by FRAP, ascorbic acid, uric acid, malondialdehyde (biomarker for oxidative stress), and hippuric acid (metabolite and potential biomarker for total polyphenol intake). HSE caused significantly higher plasma AUC of FRAP, an increase in ... of FRAP, ascorbic acid and hippuric acid, whereas malondialdehyde excretion was reduced. Furthermore, the main hibiscus anthocyanins as well as one glucuronide conjugate could be quantified in the volunteers' urine (0.02% of the administered dose). The aqueous HSE investigated in this study enhanced the systemic AOP and reduced the oxidative stress in humans. Furthermore, the increased urinary hippuric acid excretion after HSE consumption indicates a high biotransformation of the ingested HSE polyphenols, most likely caused by the colonic microbiota. (ProQuest: ... denotes formulae/symbols omitted.) BACKGROUND: To evaluate health benefits attributed to Hibiscus sabdariffa L. a randomized, open‐label, two‐way crossover study was undertaken to compare the impact of an aqueous H. sabdariffa L. extract (HSE) on the systemic antioxidant potential (AOP; assayed by ferric reducing antioxidant power (FRAP)) with a reference treatment (water) in eight healthy volunteers. The biokinetic variables were the areas under the curve (AUC) of plasma FRAP, ascorbic acid and urate that are above the pre‐dose concentration, and the amounts excreted into urine within 24 h (Ae0–24) of antioxidants as assayed by FRAP, ascorbic acid, uric acid, malondialdehyde (biomarker for oxidative stress), and hippuric acid (metabolite and potential biomarker for total polyphenol intake). RESULTS: HSE caused significantly higher plasma AUC of FRAP, an increase in Ae0–24 of FRAP, ascorbic acid and hippuric acid, whereas malondialdehyde excretion was reduced. Furthermore, the main hibiscus anthocyanins as well as one glucuronide conjugate could be quantified in the volunteers' urine (0.02% of the administered dose). CONCLUSION: The aqueous HSE investigated in this study enhanced the systemic AOP and reduced the oxidative stress in humans. Furthermore, the increased urinary hippuric acid excretion after HSE consumption indicates a high biotransformation of the ingested HSE polyphenols, most likely caused by the colonic microbiota. Copyright © 2012 Society of Chemical Industry BACKGROUND: To evaluate health benefits attributed to Hibiscus sabdariffa L. a randomized, open‐label, two‐way crossover study was undertaken to compare the impact of an aqueous H. sabdariffa L. extract (HSE) on the systemic antioxidant potential (AOP; assayed by ferric reducing antioxidant power (FRAP)) with a reference treatment (water) in eight healthy volunteers. The biokinetic variables were the areas under the curve (AUC) of plasma FRAP, ascorbic acid and urate that are above the pre‐dose concentration, and the amounts excreted into urine within 24 h (Ae 0–24 ) of antioxidants as assayed by FRAP, ascorbic acid, uric acid, malondialdehyde (biomarker for oxidative stress), and hippuric acid (metabolite and potential biomarker for total polyphenol intake). RESULTS: HSE caused significantly higher plasma AUC of FRAP, an increase in Ae 0–24 of FRAP, ascorbic acid and hippuric acid, whereas malondialdehyde excretion was reduced. Furthermore, the main hibiscus anthocyanins as well as one glucuronide conjugate could be quantified in the volunteers' urine (0.02% of the administered dose). CONCLUSION: The aqueous HSE investigated in this study enhanced the systemic AOP and reduced the oxidative stress in humans. Furthermore, the increased urinary hippuric acid excretion after HSE consumption indicates a high biotransformation of the ingested HSE polyphenols, most likely caused by the colonic microbiota. Copyright © 2012 Society of Chemical Industry To evaluate health benefits attributed to Hibiscus sabdariffa L. a randomized, open-label, two-way crossover study was undertaken to compare the impact of an aqueous H. sabdariffa L. extract (HSE) on the systemic antioxidant potential (AOP; assayed by ferric reducing antioxidant power (FRAP)) with a reference treatment (water) in eight healthy volunteers. The biokinetic variables were the areas under the curve (AUC) of plasma FRAP, ascorbic acid and urate that are above the pre-dose concentration, and the amounts excreted into urine within 24 h (Ae(0-24) ) of antioxidants as assayed by FRAP, ascorbic acid, uric acid, malondialdehyde (biomarker for oxidative stress), and hippuric acid (metabolite and potential biomarker for total polyphenol intake). HSE caused significantly higher plasma AUC of FRAP, an increase in Ae(0-24) of FRAP, ascorbic acid and hippuric acid, whereas malondialdehyde excretion was reduced. Furthermore, the main hibiscus anthocyanins as well as one glucuronide conjugate could be quantified in the volunteers' urine (0.02% of the administered dose). The aqueous HSE investigated in this study enhanced the systemic AOP and reduced the oxidative stress in humans. Furthermore, the increased urinary hippuric acid excretion after HSE consumption indicates a high biotransformation of the ingested HSE polyphenols, most likely caused by the colonic microbiota. BACKGROUND: To evaluate health benefits attributed to Hibiscus sabdariffa L. a randomized, open‐label, two‐way crossover study was undertaken to compare the impact of an aqueous H. sabdariffa L. extract (HSE) on the systemic antioxidant potential (AOP; assayed by ferric reducing antioxidant power (FRAP)) with a reference treatment (water) in eight healthy volunteers. The biokinetic variables were the areas under the curve (AUC) of plasma FRAP, ascorbic acid and urate that are above the pre‐dose concentration, and the amounts excreted into urine within 24 h (Ae0–24) of antioxidants as assayed by FRAP, ascorbic acid, uric acid, malondialdehyde (biomarker for oxidative stress), and hippuric acid (metabolite and potential biomarker for total polyphenol intake). RESULTS: HSE caused significantly higher plasma AUC of FRAP, an increase in Ae0–24 of FRAP, ascorbic acid and hippuric acid, whereas malondialdehyde excretion was reduced. Furthermore, the main hibiscus anthocyanins as well as one glucuronide conjugate could be quantified in the volunteers' urine (0.02% of the administered dose). CONCLUSION: The aqueous HSE investigated in this study enhanced the systemic AOP and reduced the oxidative stress in humans. Furthermore, the increased urinary hippuric acid excretion after HSE consumption indicates a high biotransformation of the ingested HSE polyphenols, most likely caused by the colonic microbiota. |
| Author | Carle, Reinhold Netzel, Gabriele Kammerer, Dietmar R Bitsch, Irmgard Kler, Adolf Bitsch, Roland Frank, Thomas Netzel, Michael Kriesl, Erwin |
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| Keywords | Malvaceae Human antioxidant potential polyphenols Hippuric acid Healthy subject Extract Antioxidant Hibiscus Polyphenol Dicotyledones Angiospermae Hibiscus sabdariffa L Spermatophyta malondialdehyde humans |
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| Publisher | John Wiley & Sons, Ltd Wiley John Wiley and Sons, Limited |
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| References | Ghiselli A, Serafini M, Natella F and Scaccini C, Total antioxidant capacity as a tool to assess redox status: critical view and experimental data. Free Radic Biol Med 29: 1106-1114 (2000). Mazza G and Miniati E, Anthocyanins in Fruits, Vegetables, and Grains. CRC Press, Boca Raton, FL (1993). Mulder TP, Rietveld AG and van Amelsvoort JM, Consumption of both black tea and green tea results in an increase in the excretion of hippuric acid into urine. Am J Clin Nutr 81: 256S-260S (2005). McKay DL, Chen CY, Saltzman E and Blumberg JB, Hibiscus sabdariffa L. tea (tisane) lowers blood pressure in prehypertensive and mildly hypertensive adults. J Nutr 140: 298-303 (2010). Schlesier K, Harwat M, Böhm V and Bitsch R, Assessment of antioxidant activity by using different in vitro methods. Free Radic Res 36: 177-187 (2002). Leenen R, Roodenburg AJ, Tijburg LB and Wiseman SA, A single dose of tea with or without milk increases plasma antioxidant activity in humans. Eur J Clin Nutr 54: 87-92 (2000). Harada M, Kan Y, Naoki H, Fukui Y, Kageyama N, Nakai M, et al, Identification of the major antioxidative metabolites in biological fluids of the rat with ingested (+)-catechin and (−)-epicatechin. Biosci Biotechnol Biochem 63: 973-977 (1999). Gorelik S, Ligumsky M, Kohen R and Kanner J, A novel function of red wine polyphenols in humans: prevention of absorption of cytotoxic lipid peroxidation products. FASEB J 22: 41-46 (2008). Huang D, Ou B and Prior RL, The chemistry behind antioxidant capacity assays. J Agric Food Chem 53: 1841-1856 (2005). Ali BH, Al WN and Blunden G, Phytochemical, pharmacological and toxicological aspects of Hibiscus sabdariffa L.: a review. Phytother Res 19: 369-375 (2005). Ross MA, Determination of ascorbic acid and uric acid in plasma by high-performance liquid chromatography. J Chromatogr 657: 197-200 (1994). Peng CH, Chyau CC, Chan KC, Chan TH, Wang CJ and Huang CN, Hibiscus sabdariffa polyphenolic extract inhibits hyperglycemia, hyperlipidemia, and glycation-oxidative stress while improving insulin resistance. J Agric Food Chem 59: 9901-9909 (2011). Duthie GG, Pedersen MW, Gardner PT, Morrice PC, Jenkinson AM, McPhail DB, et al, The effect of whisky and wine consumption on total phenol content and antioxidant capacity of plasma from healthy volunteers. Eur J Clin Nutr 52: 733-736 (1998). Kubota K, Horai Y, Kushida K and Ishizaki T, Determination of benzoic acid and hippuric acid in human plasma and urine by high-performance liquid chromatography. J Chromatogr 425: 67-75 (1988). Lin HH, Chen JH and Wang CJ, Chemopreventive properties and molecular mechanisms of the bioactive compounds in Hibiscus sabdariffa Linne. Curr Med Chem 18: 1245-1254 (2011). Felgines C, Talavera S, Gonthier MP, Texier O, Scalbert A, Lamaison JL, et al, Strawberry anthocyanins are recovered in urine as glucuro- and sulfoconjugates in humans. J Nutr 133: 1296-1301 (2003). Wu X, Beecher GR, Holden JM, Haytowitz DB, Gebhardt SE and Prior RL, Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption. J Agric Food Chem 54: 4069-4075 (2006). Clifford MN, Copeland EL, Bloxsidge JP and Mitchell LA, Hippuric acid as a major excretion product associated with black tea consumption. Xenobiotica 30: 317-326 (2000). Kammerer D, Claus A, Carle R and Schieber A, Polyphenol screening of pomace from red and white grape varieties (Vitis vinifera L.) by HPLC-DAD-MS/MS. J Agric Food Chem 52: 4360-4367 (2004). Woodward G, Kroon P, Cassidy A and Kay C, Anthocyanin stability and recovery: implications for the analysis of clinical and experimental samples. J Agric Food Chem 57: 5271-5278 (2009). Benzie IF and Strain JJ, The ferric reducing ability of plasma (FRAP) as a measure of 'antioxidant power': the FRAP assay. Anal Biochem 239: 70-76 (1996). Fernandez-Pachon MS, Villano D, Troncoso AM and Garcia-Parrilla MC, Antioxidant capacity of plasma after red wine intake in human volunteers. J Agric Food Chem 53: 5024-5029 (2005). Williamson G and Clifford MN, Colonic metabolites of berry polyphenols: the missing link to biological activity? Br J Nutr 104:(Suppl 3): S48-S66 (2010). Suttnar J, Cermak J and Dyr JE, Solid-phase extraction in malondialdehyde analysis. Anal Biochem 249: 20-23 (1997). Moon JH, Tsushida T, Nakahara K and Terao J, Identification of quercetin 3-O-beta-D-glucuronide as an antioxidative metabolite in rat plasma after oral administration of quercetin. Free Radic Biol Med 30: 1274-1285 (2001). Hou DX, Tong X, Terahara N, Luo D and Fujii M, Delphinidin 3-sambubioside, a Hibiscus anthocyanin, induces apoptosis in human leukemia cells through reactive oxygen species-mediated mitochondrial pathway. Arch Biochem Biophys 440: 101-109 (2005). Manach C, Williamson G, Morand C, Scalbert A and Remesy C, Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81: 230S-242S (2005). DuPont MS, Bennett RN, Mellon FA and Williamson G, Polyphenols from alcoholic apple cider are absorbed, metabolized and excreted by humans. J Nutr 132: 172-175 (2002). Volpi N and Tarugi P, Improvement in the high-performance liquid chromatography malondialdehyde level determination in normal human plasma. J Chromatogr B Biomed Sci Appl 713: 433-437 (1998). Kaliora AC and Dedoussis GV, Natural antioxidant compounds in risk factors for CVD. Pharmacol Res 56: 99-109 (2007). Miyazawa T, Nakagawa K, Kudo M, Muraishi K and Someya K, Direct intestinal absorption of red fruit anthocyanins, cyanidin-3-glucoside and cyanidin-3,5-diglucoside, into rats and humans. J Agric Food Chem 47: 1083-1091 (1999). Vitaglione P, Donnarumma G, Napolitano A, Galvano F, Gallo A, Scalfi L, et al, Protocatechuic acid is the major human metabolite of cyanidin-glucosides. J Nutr 137: 2043-2048 (2007). Korchazhkina O, Exley C and Spencer SA, Measurement by reverse-phased high-performance liquid chromatography of malondialdehyde in normal human urine following derivatisation with 2,4-dinitrophenylhydrazine. J Chromatogr 794: 353-362 (2003). Serafini M, Maiani G and Ferro-Luzzi A, Alcohol-free red wine enhances plasma antioxidant capacity in humans. J Nutr 128: 1003-1007 (1998). Cao G, Russell RM, Lischner N and Prior RL, Serum antioxidant capacity is increased by consumption of strawberries, spinach, red wine or vitamin C in elderly women. J Nutr 128: 2383-2390 (1998). Natsume M, Osakabe N, Yasuda A, Baba S, Tokunaga T, Kondo K, et al, In vitro antioxidative activity of (-)-epicatechin glucuronide metabolites present in human and rat plasma. Free Radic Res 38: 1341-1348 (2004). Piche LA, Draper HH and Cole PD, Malondialdehyde excretion by subjects consuming cod liver oil vs a concentrate of n-3 fatty acids. Lipids 23: 370-371 (1988). Weinbrenner T, Fito M, de la Torre R, Saez GT, Rijken P, Tormos C, et al, Olive oils high in phenolic compounds modulate oxidative/antioxidative status in men. J Nutr 134: 2314-2321 (2004). Singleton VL and Rossi JA, Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Vitic 16: 144-158 (1965). Böhm V, Fröhlich K and Bitsch R, Rosehip: a 'new' source of lycopene? Mol Aspects Med 24: 385-389 (2003). Lin HH, Huang HP, Huang CC, Chen JH and Wang CJ, Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway. Mol Carcinog 43: 86-99 (2005). Lotito SB and Frei B, The increase in human plasma antioxidant capacity after apple consumption is due to the metabolic effect of fructose on urate, not apple-derived antioxidant flavonoids. Free Radic Biol Med 37: 251-258 (2004). Vazquez Odirez ML, Vazquez Blanco ME, Lopez Hernandes J, Simal Lozano J and Romero Rodriguez MA, Simultaneous determination of organic acids and vitamin C in green beans by liquid chromatography. J AOAC Int 77: 1056-1059 (1994). van Dorsten FA, Grun CH, van Velzen EJ, Jacobs DM, Draijer R and van Duynhoven JP, The metabolic fate of red wine and grape juice polyphenols in humans assessed by metabolomics. Mol Nutr Food Res 54: 897-908 (2010). Frank T, Janssen M, Netzel M, Strass G, Kler A, Kriesl E, et al, Pharmacokinetics of anthocyanidin-3-glycosides following consumption of Hibiscus sabdariffa L. extract. J Clin Pharmacol 45: 203-210 (2005). Price RK, Welch RW, Lee-Manion AM, Bradbury I and Strain JJ, Total phenolics and antioxidant potential in plasma and urine of humans after consumption of wheat bran. Cereal Chem 85: 152-157 (2008). Khan N, Afaq F and Mukhtar H, Cancer chemoprevention through dietary antioxidants: progress and promise. Antioxid Redox Signal 10: 475-510 (2008). Prior RL, Wu X and Schaich K, Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements. J Agric Food Chem 53: 4290-4302 (2005). Tepel M, van der Giet M and Zidek W, [Antioxidant therapy in vascular and renal diseases]. Med Klin (Munich) 97: 144-151 (2002). 2002; 36 2010; 54 2000; 29 2002; 132 2002; 97 2010 2006; 54 2010; 104 1999; 47 1998; 713 2008 2005; 43 2008; 10 2005; 81 1993 2010; 140 1999; 63 2011; 59 1965; 16 1994; 657 2007; 56 2011; 18 2003; 794 2003; 133 1988; 425 2005; 45 2004; 134 2007; 137 2004; 52 2009; 57 2005; 19 1997; 249 2005; 440 2004; 38 2000; 54 2004; 37 2000; 30 2003; 24 1987 1994; 77 2005; 53 1988; 23 2008; 22 1998; 128 2008; 85 1998; 52 1996; 239 2001; 30 e_1_2_7_5_2 e_1_2_7_3_2 e_1_2_7_7_2 e_1_2_7_19_2 e_1_2_7_17_2 e_1_2_7_15_2 e_1_2_7_13_2 e_1_2_7_41_2 e_1_2_7_11_2 e_1_2_7_43_2 e_1_2_7_45_2 Mazza G (e_1_2_7_9_2) 1993 e_1_2_7_47_2 e_1_2_7_49_2 e_1_2_7_28_2 e_1_2_7_50_2 e_1_2_7_25_2 e_1_2_7_52_2 e_1_2_7_23_2 e_1_2_7_31_2 e_1_2_7_21_2 e_1_2_7_33_2 e_1_2_7_35_2 e_1_2_7_37_2 e_1_2_7_39_2 Morton JF (e_1_2_7_6_2) 1987 e_1_2_7_4_2 Vazquez Odirez ML (e_1_2_7_26_2) 1994; 77 e_1_2_7_2_2 e_1_2_7_8_2 e_1_2_7_18_2 e_1_2_7_16_2 e_1_2_7_14_2 e_1_2_7_40_2 e_1_2_7_12_2 e_1_2_7_42_2 e_1_2_7_10_2 e_1_2_7_44_2 e_1_2_7_46_2 e_1_2_7_48_2 e_1_2_7_27_2 e_1_2_7_29_2 e_1_2_7_24_2 e_1_2_7_30_2 e_1_2_7_51_2 e_1_2_7_22_2 e_1_2_7_32_2 e_1_2_7_53_2 e_1_2_7_20_2 e_1_2_7_34_2 e_1_2_7_36_2 e_1_2_7_38_2 |
| References_xml | – reference: Peng CH, Chyau CC, Chan KC, Chan TH, Wang CJ and Huang CN, Hibiscus sabdariffa polyphenolic extract inhibits hyperglycemia, hyperlipidemia, and glycation-oxidative stress while improving insulin resistance. J Agric Food Chem 59: 9901-9909 (2011). – reference: van Dorsten FA, Grun CH, van Velzen EJ, Jacobs DM, Draijer R and van Duynhoven JP, The metabolic fate of red wine and grape juice polyphenols in humans assessed by metabolomics. Mol Nutr Food Res 54: 897-908 (2010). – reference: Huang D, Ou B and Prior RL, The chemistry behind antioxidant capacity assays. J Agric Food Chem 53: 1841-1856 (2005). – reference: Singleton VL and Rossi JA, Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Vitic 16: 144-158 (1965). – reference: Frank T, Janssen M, Netzel M, Strass G, Kler A, Kriesl E, et al, Pharmacokinetics of anthocyanidin-3-glycosides following consumption of Hibiscus sabdariffa L. extract. J Clin Pharmacol 45: 203-210 (2005). – reference: Duthie GG, Pedersen MW, Gardner PT, Morrice PC, Jenkinson AM, McPhail DB, et al, The effect of whisky and wine consumption on total phenol content and antioxidant capacity of plasma from healthy volunteers. Eur J Clin Nutr 52: 733-736 (1998). – reference: Harada M, Kan Y, Naoki H, Fukui Y, Kageyama N, Nakai M, et al, Identification of the major antioxidative metabolites in biological fluids of the rat with ingested (+)-catechin and (−)-epicatechin. Biosci Biotechnol Biochem 63: 973-977 (1999). – reference: Wu X, Beecher GR, Holden JM, Haytowitz DB, Gebhardt SE and Prior RL, Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption. J Agric Food Chem 54: 4069-4075 (2006). – reference: Woodward G, Kroon P, Cassidy A and Kay C, Anthocyanin stability and recovery: implications for the analysis of clinical and experimental samples. J Agric Food Chem 57: 5271-5278 (2009). – reference: Leenen R, Roodenburg AJ, Tijburg LB and Wiseman SA, A single dose of tea with or without milk increases plasma antioxidant activity in humans. Eur J Clin Nutr 54: 87-92 (2000). – reference: Kaliora AC and Dedoussis GV, Natural antioxidant compounds in risk factors for CVD. Pharmacol Res 56: 99-109 (2007). – reference: Clifford MN, Copeland EL, Bloxsidge JP and Mitchell LA, Hippuric acid as a major excretion product associated with black tea consumption. Xenobiotica 30: 317-326 (2000). – reference: Korchazhkina O, Exley C and Spencer SA, Measurement by reverse-phased high-performance liquid chromatography of malondialdehyde in normal human urine following derivatisation with 2,4-dinitrophenylhydrazine. J Chromatogr 794: 353-362 (2003). – reference: Mulder TP, Rietveld AG and van Amelsvoort JM, Consumption of both black tea and green tea results in an increase in the excretion of hippuric acid into urine. Am J Clin Nutr 81: 256S-260S (2005). – reference: Hou DX, Tong X, Terahara N, Luo D and Fujii M, Delphinidin 3-sambubioside, a Hibiscus anthocyanin, induces apoptosis in human leukemia cells through reactive oxygen species-mediated mitochondrial pathway. Arch Biochem Biophys 440: 101-109 (2005). – reference: Miyazawa T, Nakagawa K, Kudo M, Muraishi K and Someya K, Direct intestinal absorption of red fruit anthocyanins, cyanidin-3-glucoside and cyanidin-3,5-diglucoside, into rats and humans. J Agric Food Chem 47: 1083-1091 (1999). – reference: Lin HH, Huang HP, Huang CC, Chen JH and Wang CJ, Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway. Mol Carcinog 43: 86-99 (2005). – reference: Serafini M, Maiani G and Ferro-Luzzi A, Alcohol-free red wine enhances plasma antioxidant capacity in humans. J Nutr 128: 1003-1007 (1998). – reference: Lin HH, Chen JH and Wang CJ, Chemopreventive properties and molecular mechanisms of the bioactive compounds in Hibiscus sabdariffa Linne. Curr Med Chem 18: 1245-1254 (2011). – reference: Lotito SB and Frei B, The increase in human plasma antioxidant capacity after apple consumption is due to the metabolic effect of fructose on urate, not apple-derived antioxidant flavonoids. Free Radic Biol Med 37: 251-258 (2004). – reference: Manach C, Williamson G, Morand C, Scalbert A and Remesy C, Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81: 230S-242S (2005). – reference: Mazza G and Miniati E, Anthocyanins in Fruits, Vegetables, and Grains. CRC Press, Boca Raton, FL (1993). – reference: Ross MA, Determination of ascorbic acid and uric acid in plasma by high-performance liquid chromatography. J Chromatogr 657: 197-200 (1994). – reference: DuPont MS, Bennett RN, Mellon FA and Williamson G, Polyphenols from alcoholic apple cider are absorbed, metabolized and excreted by humans. J Nutr 132: 172-175 (2002). – reference: Kammerer D, Claus A, Carle R and Schieber A, Polyphenol screening of pomace from red and white grape varieties (Vitis vinifera L.) by HPLC-DAD-MS/MS. J Agric Food Chem 52: 4360-4367 (2004). – reference: Prior RL, Wu X and Schaich K, Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements. J Agric Food Chem 53: 4290-4302 (2005). – reference: Fernandez-Pachon MS, Villano D, Troncoso AM and Garcia-Parrilla MC, Antioxidant capacity of plasma after red wine intake in human volunteers. J Agric Food Chem 53: 5024-5029 (2005). – reference: Vitaglione P, Donnarumma G, Napolitano A, Galvano F, Gallo A, Scalfi L, et al, Protocatechuic acid is the major human metabolite of cyanidin-glucosides. J Nutr 137: 2043-2048 (2007). – reference: McKay DL, Chen CY, Saltzman E and Blumberg JB, Hibiscus sabdariffa L. tea (tisane) lowers blood pressure in prehypertensive and mildly hypertensive adults. J Nutr 140: 298-303 (2010). – reference: Gorelik S, Ligumsky M, Kohen R and Kanner J, A novel function of red wine polyphenols in humans: prevention of absorption of cytotoxic lipid peroxidation products. FASEB J 22: 41-46 (2008). – reference: Ali BH, Al WN and Blunden G, Phytochemical, pharmacological and toxicological aspects of Hibiscus sabdariffa L.: a review. Phytother Res 19: 369-375 (2005). – reference: Khan N, Afaq F and Mukhtar H, Cancer chemoprevention through dietary antioxidants: progress and promise. Antioxid Redox Signal 10: 475-510 (2008). – reference: Felgines C, Talavera S, Gonthier MP, Texier O, Scalbert A, Lamaison JL, et al, Strawberry anthocyanins are recovered in urine as glucuro- and sulfoconjugates in humans. J Nutr 133: 1296-1301 (2003). – reference: Ghiselli A, Serafini M, Natella F and Scaccini C, Total antioxidant capacity as a tool to assess redox status: critical view and experimental data. Free Radic Biol Med 29: 1106-1114 (2000). – reference: Benzie IF and Strain JJ, The ferric reducing ability of plasma (FRAP) as a measure of 'antioxidant power': the FRAP assay. Anal Biochem 239: 70-76 (1996). – reference: Weinbrenner T, Fito M, de la Torre R, Saez GT, Rijken P, Tormos C, et al, Olive oils high in phenolic compounds modulate oxidative/antioxidative status in men. J Nutr 134: 2314-2321 (2004). – reference: Volpi N and Tarugi P, Improvement in the high-performance liquid chromatography malondialdehyde level determination in normal human plasma. J Chromatogr B Biomed Sci Appl 713: 433-437 (1998). – reference: Cao G, Russell RM, Lischner N and Prior RL, Serum antioxidant capacity is increased by consumption of strawberries, spinach, red wine or vitamin C in elderly women. J Nutr 128: 2383-2390 (1998). – reference: Kubota K, Horai Y, Kushida K and Ishizaki T, Determination of benzoic acid and hippuric acid in human plasma and urine by high-performance liquid chromatography. J Chromatogr 425: 67-75 (1988). – reference: Tepel M, van der Giet M and Zidek W, [Antioxidant therapy in vascular and renal diseases]. Med Klin (Munich) 97: 144-151 (2002). – reference: Suttnar J, Cermak J and Dyr JE, Solid-phase extraction in malondialdehyde analysis. Anal Biochem 249: 20-23 (1997). – reference: Schlesier K, Harwat M, Böhm V and Bitsch R, Assessment of antioxidant activity by using different in vitro methods. Free Radic Res 36: 177-187 (2002). – reference: Natsume M, Osakabe N, Yasuda A, Baba S, Tokunaga T, Kondo K, et al, In vitro antioxidative activity of (-)-epicatechin glucuronide metabolites present in human and rat plasma. Free Radic Res 38: 1341-1348 (2004). – reference: Moon JH, Tsushida T, Nakahara K and Terao J, Identification of quercetin 3-O-beta-D-glucuronide as an antioxidative metabolite in rat plasma after oral administration of quercetin. Free Radic Biol Med 30: 1274-1285 (2001). – reference: Böhm V, Fröhlich K and Bitsch R, Rosehip: a 'new' source of lycopene? Mol Aspects Med 24: 385-389 (2003). – reference: Piche LA, Draper HH and Cole PD, Malondialdehyde excretion by subjects consuming cod liver oil vs a concentrate of n-3 fatty acids. Lipids 23: 370-371 (1988). – reference: Williamson G and Clifford MN, Colonic metabolites of berry polyphenols: the missing link to biological activity? Br J Nutr 104:(Suppl 3): S48-S66 (2010). – reference: Vazquez Odirez ML, Vazquez Blanco ME, Lopez Hernandes J, Simal Lozano J and Romero Rodriguez MA, Simultaneous determination of organic acids and vitamin C in green beans by liquid chromatography. J AOAC Int 77: 1056-1059 (1994). – reference: Price RK, Welch RW, Lee-Manion AM, Bradbury I and Strain JJ, Total phenolics and antioxidant potential in plasma and urine of humans after consumption of wheat bran. Cereal Chem 85: 152-157 (2008). – volume: 140 start-page: 298 year: 2010 end-page: 303 article-title: L. tea (tisane) lowers blood pressure in prehypertensive and mildly hypertensive adults publication-title: J Nutr – volume: 18 start-page: 1245 year: 2011 end-page: 1254 article-title: Chemopreventive properties and molecular mechanisms of the bioactive compounds in Linne publication-title: Curr Med Chem – volume: 85 start-page: 152 year: 2008 end-page: 157 article-title: Total phenolics and antioxidant potential in plasma and urine of humans after consumption of wheat bran publication-title: Cereal Chem – volume: 54 start-page: 4069 year: 2006 end-page: 4075 article-title: Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption publication-title: J Agric Food Chem – volume: 440 start-page: 101 year: 2005 end-page: 109 article-title: Delphinidin 3‐sambubioside, a anthocyanin, induces apoptosis in human leukemia cells through reactive oxygen species‐mediated mitochondrial pathway publication-title: Arch Biochem Biophys – volume: 23 start-page: 370 year: 1988 end-page: 371 article-title: Malondialdehyde excretion by subjects consuming cod liver oil vs a concentrate of n‐3 fatty acids publication-title: Lipids – start-page: 163 year: 2010 end-page: 187 – volume: 10 start-page: 475 year: 2008 end-page: 510 article-title: Cancer chemoprevention through dietary antioxidants: progress and promise publication-title: Antioxid Redox Signal – volume: 77 start-page: 1056 year: 1994 end-page: 1059 article-title: Simultaneous determination of organic acids and vitamin C in green beans by liquid chromatography publication-title: J AOAC Int – volume: 425 start-page: 67 year: 1988 end-page: 75 article-title: Determination of benzoic acid and hippuric acid in human plasma and urine by high‐performance liquid chromatography publication-title: J Chromatogr – volume: 30 start-page: 1274 year: 2001 end-page: 1285 article-title: Identification of quercetin 3‐ ‐beta‐ ‐glucuronide as an antioxidative metabolite in rat plasma after oral administration of quercetin publication-title: Free Radic Biol Med – volume: 249 start-page: 20 year: 1997 end-page: 23 article-title: Solid‐phase extraction in malondialdehyde analysis publication-title: Anal Biochem – volume: 29 start-page: 1106 year: 2000 end-page: 1114 article-title: Total antioxidant capacity as a tool to assess redox status: critical view and experimental data publication-title: Free Radic Biol Med – year: 2008 – volume: 53 start-page: 4290 year: 2005 end-page: 4302 article-title: Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements publication-title: J Agric Food Chem – volume: 63 start-page: 973 year: 1999 end-page: 977 article-title: Identification of the major antioxidative metabolites in biological fluids of the rat with ingested (+)‐catechin and (−)‐epicatechin publication-title: Biosci Biotechnol Biochem – volume: 657 start-page: 197 year: 1994 end-page: 200 article-title: Determination of ascorbic acid and uric acid in plasma by high‐performance liquid chromatography publication-title: J Chromatogr – volume: 52 start-page: 4360 year: 2004 end-page: 4367 article-title: Polyphenol screening of pomace from red and white grape varieties ( L.) by HPLC‐DAD‐MS/MS publication-title: J Agric Food Chem – volume: 81 start-page: 230S year: 2005 end-page: 242S article-title: Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies publication-title: Am J Clin Nutr – year: 1993 – volume: 53 start-page: 1841 year: 2005 end-page: 1856 article-title: The chemistry behind antioxidant capacity assays publication-title: J Agric Food Chem – volume: 54 start-page: 897 year: 2010 end-page: 908 article-title: The metabolic fate of red wine and grape juice polyphenols in humans assessed by metabolomics publication-title: Mol Nutr Food Res – volume: 52 start-page: 733 year: 1998 end-page: 736 article-title: The effect of whisky and wine consumption on total phenol content and antioxidant capacity of plasma from healthy volunteers publication-title: Eur J Clin Nutr – volume: 133 start-page: 1296 year: 2003 end-page: 1301 article-title: Strawberry anthocyanins are recovered in urine as glucuro‐ and sulfoconjugates in humans publication-title: J Nutr – volume: 128 start-page: 1003 year: 1998 end-page: 1007 article-title: Alcohol‐free red wine enhances plasma antioxidant capacity in humans publication-title: J Nutr – volume: 713 start-page: 433 year: 1998 end-page: 437 article-title: Improvement in the high‐performance liquid chromatography malondialdehyde level determination in normal human plasma publication-title: J Chromatogr B Biomed Sci Appl – volume: 54 start-page: 87 year: 2000 end-page: 92 article-title: A single dose of tea with or without milk increases plasma antioxidant activity in humans publication-title: Eur J Clin Nutr – volume: 104 start-page: S48 year: 2010 end-page: S66 article-title: Colonic metabolites of berry polyphenols: the missing link to biological activity? publication-title: Br J Nutr – volume: 132 start-page: 172 year: 2002 end-page: 175 article-title: Polyphenols from alcoholic apple cider are absorbed, metabolized and excreted by humans publication-title: J Nutr – volume: 36 start-page: 177 year: 2002 end-page: 187 article-title: Assessment of antioxidant activity by using different methods publication-title: Free Radic Res – volume: 43 start-page: 86 year: 2005 end-page: 99 article-title: polyphenol‐rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway publication-title: Mol Carcinog – volume: 134 start-page: 2314 year: 2004 end-page: 2321 article-title: Olive oils high in phenolic compounds modulate oxidative/antioxidative status in men publication-title: J Nutr – volume: 57 start-page: 5271 year: 2009 end-page: 5278 article-title: Anthocyanin stability and recovery: implications for the analysis of clinical and experimental samples publication-title: J Agric Food Chem – volume: 24 start-page: 385 year: 2003 end-page: 389 article-title: Rosehip: a ‘new’ source of lycopene? publication-title: Mol Aspects Med – volume: 53 start-page: 5024 year: 2005 end-page: 5029 article-title: Antioxidant capacity of plasma after red wine intake in human volunteers publication-title: J Agric Food Chem – volume: 239 start-page: 70 year: 1996 end-page: 76 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| Snippet | BACKGROUND: To evaluate health benefits attributed to Hibiscus sabdariffa L. a randomized, open‐label, two‐way crossover study was undertaken to compare the... BACKGROUND: To evaluate health benefits attributed to Hibiscus sabdariffa L. a randomized, open‐label, two‐way crossover study was undertaken to compare the... To evaluate health benefits attributed to Hibiscus sabdariffa L. a randomized, open-label, two-way crossover study was undertaken to compare the impact of an... |
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| SubjectTerms | administered dose Adult anthocyanins Anthocyanins - pharmacology Anthocyanins - urine antioxidant activity antioxidant potential Antioxidants Antioxidants - metabolism Antioxidants - pharmacology Aqueous solutions Area Under Curve ascorbic acid Ascorbic Acid - blood Biological and medical sciences Biomarkers Biomarkers - metabolism Biotransformation blood chemistry drug effects excretion Extraction processes Female Flowers & plants Food industries Food science Fundamental and applied biological sciences. Psychology Glucuronides Glucuronides - pharmacology Glucuronides - urine Health Hibiscus Hibiscus - chemistry Hibiscus sabdariffa Hibiscus sabdariffa L Hippurates Hippurates - urine hippuric acid Humans Male malondialdehyde Malondialdehyde - urine metabolism Oxidative stress Oxidative Stress - drug effects pharmacology Plant Extracts Plant Extracts - pharmacology polyphenols Polyphenols - pharmacology Polyphenols - urine Reference Values uric acid Uric Acid - blood urine volunteers Young Adult |
| Title | Consumption of Hibiscus sabdariffa L. aqueous extract and its impact on systemic antioxidant potential in healthy subjects |
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