Impaired corticopontocerebellar tracts underlie pseudobulbar affect in motor neuron disorders

• Published in: Neurology Vol. 83; no. 7; p. 620
• Main Authors: Floeter, Mary Kay, Katipally, Rohan, Kim, Meredith P, Schanz, Olivia, Stephen, Matthew, Danielian, Laura, Wu, Tianxia, Huey, Edward D, Meoded, Avner
• Format: Journal Article
• Language: English
• Published: United States 12.08.2014
• Subjects: Amyotrophic Lateral Sclerosis - pathology; Amyotrophic Lateral Sclerosis - psychology; Anisotropy; Cerebellum - pathology; Cerebral Cortex - pathology; Diffusion Tensor Imaging; Female; Humans; Male; Middle Aged; Mood Disorders - epidemiology; Mood Disorders - pathology; Motor Neuron Disease - pathology; Motor Neuron Disease - psychology; Nerve Fibers, Myelinated - pathology; Neural Pathways - pathology; Pons - pathology; Prevalence; Pyramidal Tracts - pathology; Retrospective Studies

The objectives of the study were (1) to determine the prevalence and characteristics of pseudobulbar affect (PBA) in patients with primary lateral sclerosis (PLS) and amyotrophic lateral sclerosis (ALS) in an outpatient clinic population, and (2) to test the hypothesis that damage of inputs to the c...