Alvimopan, a peripherally acting mu-opioid receptor (PAM-OR) antagonist for the treatment of opioid-induced bowel dysfunction: Results from a randomized, double-blind, placebo-controlled, dose-finding study in subjects taking opioids for chronic non-cancer pain - Webster, Lynn; Jansen, Jan Peter; Peppin, John; Lasko, Ben; Irving, Gordon; Morlion, Bart; Snidow, Jerry; Pierce, Amy; Mortensen, Eric; Kleoudis, Christi; Carter, Eric (Pain (Amsterdam), 2008)
Keywords: Adult; Alvimopan; Analgesics; Analgesics, Opioid - adverse effects; Analgesics, Opioid - antagonists & inhibitors; Antagonist; Biological and medical sciences; Colic - chemically induced; Colic - physiopathology; Constipation; Constipation - chemically induced; Constipation - drug therapy; Constipation - physiopathology; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Enteric Nervous System - drug effects; Enteric Nervous System - metabolism; Enteric Nervous System - physiopathology; Female; Fundamental and applied biological sciences. Psychology; Gastrointestinal motility; Gastrointestinal Motility - drug effects; Gastrointestinal Motility - physiology; Humans; Illness and personality; Illness, stress and coping; Intestines - drug effects; Intestines - innervation; Intestines - physiopathology; Male; Medical sciences; Middle Aged; Narcotic Antagonists - administration & dosage; Narcotic Antagonists - adverse effects; Neuropharmacology; Opioid; Pain - drug therapy; Pharmacology. Drug treatments; Piperidines - administration & dosage; Piperidines - adverse effects; Placebos; Psychology and medicine; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Randomized controlled trial; Receptors, Opioid, mu - antagonists & inhibitors; Receptors, Opioid, mu - metabolism; Risk Assessment; Treatment Outcome; Opioid; Alvimopan; Gastrointestinal motility; Antagonist; Constipation; Randomized controlled trial; Sensation; Opioid receptor; Morphine; Nausea; Analgesia; Improvement; Pain; Treatment; Dysfunction; Risk factor; Placebo; Safety