Percutaneous Absorption of Vanilloids: In Vivo and in Vitro Studies

• Published in: Journal of pharmaceutical sciences Vol. 86; no. 1; pp. 142 - 146
• Main Authors: Kasting, Gerald B., Francis, William R., Bowman, Lisa A., Kinnett, Gene O.
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01.01.1997; John Wiley & Sons, Inc; Wiley; American Pharmaceutical Association
• Subjects: Animals; Biological and medical sciences; Capsaicin - analogs & derivatives; Capsaicin - pharmacokinetics; General pharmacology; Humans; In Vitro Techniques; Male; Medical sciences; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions; Pharmacology. Drug treatments; Rats; Skin Absorption; Vanillic Acid - analogs & derivatives; Vanillic Acid - pharmacokinetics; Human; Rat; Capsaicin; Rodentia; Elimination; Permeability; Metabolism; Nonane derivatives; In vitro; Olvanil; Percutaneous route; Lipophilic compound; In vivo; Vertebrata; Mammalia; Absorption; Animal; Skin; Pharmacokinetics

The percutaneous absorption of three highly lipophilic analogs of capsaicinsvanillylnonanamide (VN), olvanil, and NE-21610swas measured in vivo in the CD:VAF rat, and in vitro through excised CD: VAF and SkH:Fz rat skin and human cadaver skin. Absorption and skin metabolism were monitored by radiola...