Iron overload accelerates bone loss in healthy postmenopausal women and middle-aged men: A 3-year retrospective longitudinal study

• Published in: Journal of bone and mineral research Vol. 27; no. 11; pp. 2279 - 2290
• Main Authors: Kim, Beom-Jun, Ahn, Seong Hee, Bae, Sung Jin, Kim, Eun Hee, Lee, Seung-Hun, Kim, Hong-Kyu, Choe, Jae Won, Koh, Jung-Min, Kim, Ghi Su
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.11.2012; Wiley; Oxford University Press
• Subjects: Adult; Age; Aged; Aged, 80 and over; Biological and medical sciences; Biomarkers - blood; Bone Density - physiology; BONE LOSS; BONE MINERAL DENSITY; Bone Resorption - blood; Bone Resorption - etiology; Bone Resorption - physiopathology; Bone turnover; Confidence Intervals; Data processing; Dual energy X-ray absorptiometry; Female; Femur; Femur - pathology; Femur - physiopathology; FERRITIN; Ferritins - blood; Fundamental and applied biological sciences. Psychology; Health; Humans; Iron; IRON OVERLOAD; Iron Overload - blood; Iron Overload - complications; Iron Overload - physiopathology; Longitudinal Studies; Male; Middle Aged; Neck; Odds Ratio; Post-menopause; Postmenopause - blood; Postmenopause - physiology; Regression Analysis; Republic of Korea; Retrospective Studies; Risk factors; Skeleton and joints; Trochanter; Vertebrates: osteoarticular system, musculoskeletal system; Republic of Korea; Human; Iron overload; Diseases of the osteoarticular system; Ferritin; Metabolic diseases; Osteoarticular system; Vertebrata; Mammalia; BONE LOSS; Postmenopause; Female; Bone mineral density; Osteopenia

Despite extensive experimental and animal evidence about the detrimental effects of iron and its overload on bone metabolism, there have been no clinical studies relating iron stores to bone loss, especially in nonpathologic conditions. In the present study, we performed a large longitudinal study t...