Diagnostic Value of Flecainide Testing in Unmasking SCN5A-Related Brugada Syndrome

• Published in: Journal of cardiovascular electrophysiology Vol. 17; no. 8; pp. 857 - 864
• Main Authors: MEREGALLI, PAOLA G., RUIJTER, JAN M., HOFMAN, NYNKE, BEZZINA, CONNIE R., WILDE, ARTHUR A.M., TAN, HANNO L.
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.08.2006
• Subjects: Adult; arrhythmia; Brugada syndrome; Brugada Syndrome - diagnosis; Brugada Syndrome - genetics; Brugada Syndrome - physiopathology; electrocardiogram; Electrocardiography; Female; flecainide; Flecainide - adverse effects; genetics; Humans; ion channels; Male; Middle Aged; Muscle Proteins - genetics; Mutation; NAV1.5 Voltage-Gated Sodium Channel; Retrospective Studies; Sensitivity and Specificity; Sodium Channels - genetics

Introduction: Provocation tests with sodium channel blockers are often required to unmask ECG abnormalities in Brugada syndrome (BrS). However, their diagnostic value is only partially established, while life‐threatening ventricular arrhythmias during these tests were reported. We aimed to establish...