Differences in Performance Characteristics Among Four High-Throughput Assays for the Detection of Antibodies Against SARS-CoV-2 Using a Common Set of Patient Samples

• Published in: American journal of clinical pathology Vol. 155; no. 2; pp. 267 - 279
• Main Authors: Manthei, David M, Whalen, Jason F, Schroeder, Lee F, Sinay, Anthony M, Li, Shih-Hon, Valdez, Riccardo, Giacherio, Donald A, Gherasim, Carmen
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.02.2021
• Subjects: Antibodies, Viral - blood; Coronaviruses; COVID-19 - diagnosis; COVID-19 Serological Testing - methods; Electronic components industry; Enzyme-linked immunosorbent assay; Female; Health aspects; High-Throughput Screening Assays - methods; Humans; Immunoglobulin G; Male; Original; Patients; Polymerase chain reaction; Predictive Value of Tests; Reverse transcription; SARS-CoV-2 - immunology; Sensitivity and Specificity; Serology; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; United States; COVID-19; Immunoassay; SARS-CoV-2; Specificity; Sensitivity; Coronavirus; Serology

Abstract Objectives Serologic testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has experienced a changing landscape of available assays coupled with uncertainty surrounding performance characteristics. Studies are needed to directly compare multiple commercially available ass...