Evidence for prescribing exercise as therapy in chronic disease

• Published in: Scandinavian journal of medicine & science in sports Vol. 16; no. S1; pp. 3 - 63
• Main Authors: Pedersen, B. K., Saltin, B.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Munksgaard International Publishers 01.02.2006
• Subjects: Asthma - therapy; Cardiovascular Diseases - therapy; Depression - therapy; Exercise; Exercise Tolerance; Humans; Metabolic Diseases - therapy; Motivation; Musculoskeletal Diseases - therapy; Neoplasms - therapy; Physical Fitness; Pulmonary Disease, Chronic Obstructive - therapy
• ISSN: 0905-7188; 1600-0838
• DOI: 10.1111/j.1600-0838.2006.00520.x

Considerable knowledge has accumulated in recent decades concerning the significance of physical activity in the treatment of a number of diseases, including diseases that do not primarily manifest as disorders of the locomotive apparatus. In this review we present the evidence for prescribing exercise therapy in the treatment of metabolic syndrome‐related disorders (insulin resistance, type 2 diabetes, dyslipidemia, hypertension, obesity), heart and pulmonary diseases (chronic obstructive pulmonary disease, coronary heart disease, chronic heart failure, intermittent claudication), muscle, bone and joint diseases (osteoarthritis, rheumatoid arthritis, osteoporosis, fibromyalgia, chronic fatigue syndrome) and cancer, depression, asthma and type 1 diabetes. For each disease, we review the effect of exercise therapy on disease pathogenesis, on symptoms specific to the diagnosis, on physical fitness or strength and on quality of life. The possible mechanisms of action are briefly examined and the principles for prescribing exercise therapy are discussed, focusing on the type and amount of exercise and possible contraindications.