Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial

• Published in: The American journal of clinical nutrition Vol. 108; no. 6; pp. 1249 - 1258
• Main Authors: Dai, Qi, Zhu, Xiangzhu, Manson, JoAnn E, Song, Yiqing, Li, Xingnan, Franke, Adrian A, Costello, Rebecca B, Rosanoff, Andrea, Nian, Hui, Fan, Lei, Murff, Harvey, Ness, Reid M, Seidner, Douglas L, Yu, Chang, Shrubsole, Martha J
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2018; Oxford University Press; American Society for Clinical Nutrition, Inc
• Subjects: 24,25-Dihydroxyvitamin D 3 - blood; 25-Hydroxyvitamin D; 25-Hydroxyvitamin D 2 - blood; Adults; Aged; algorithms; Calcifediol - blood; Calcitriol; Calcitriol - blood; Calcium; calcium-to-magnesium ratio; Cancer; Clinical trials; Colorectal cancer; Colorectal carcinoma; colorectal neoplasms; Diet; Dietary intake; Dietary Supplements; enzymes; Ergocalciferols - blood; Female; food intake; Health care facilities; Humans; In vivo methods and tests; in vivo studies; interaction; Kidney - physiopathology; Liquid chromatography; Magnesium; Magnesium - administration & dosage; Magnesium Deficiency - physiopathology; Male; Mass spectrometry; Mass spectroscopy; medical facilities; Metabolism; Middle Aged; mortality; Mortality risk; National Health and Nutrition Examination Survey; nutrition risk assessment; Nutritional Status; Observational studies; Optimization; Original Research Communications; Placebos; randomized clinical trial; randomized clinical trials; United States; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - physiopathology; vitamin D metabolism; vitamin status; United States; vitamin D metabolism; eGFR; PTAD; 1,25(OH)2D3; magnesium; randomized clinical trial; 1,25(OH)2D2; 1,25(OH)2D; calcium-to-magnesium ratio; CVD; NCI; interaction; NIST; PPCCT; 24,25(OH)2D3; 25(OH)D; 25(OH)D2; TRPM7; CYP; 25(OH)D3; LCMS; subfamily M

Previous in vitro and in vivo studies indicate that enzymes that synthesize and metabolize vitamin D are magnesium dependent. Recent observational studies found that magnesium intake significantly interacted with vitamin D in relation to vitamin D status and risk of mortality. According to NHANES, 7...