Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease - Agostini, Maria L.; Andres, Erica L.; Sims, Amy C.; Graham, Rachel L.; Sheahan, Timothy P.; Lu, Xiaotao; Smith, Everett Clinton; Case, James Brett; Feng, Joy Y.; Jordan, Robert; Ray, Adrian S.; Cihlar, Tomas; et al. (mBio, 2018)
Keywords: Alanine - analogs & derivatives; Alanine - pharmacology; Animals; antiviral agents; Antiviral Agents - pharmacology; antiviral resistance; coronavirus; Coronavirus - drug effects; Coronavirus - enzymology; Exoribonucleases - chemistry; Exoribonucleases - genetics; Exoribonucleases - metabolism; Mice; Mutation - genetics; nucleoside analogs; Ribonucleotides - pharmacology; RNA polymerases; SARS Virus - drug effects; SARS Virus - genetics; SARS-CoV; Virus Replication - drug effects; Virus Replication - genetics; antiviral resistance; nucleoside analogs; antiviral agents; SARS-CoV; coronavirus; pandemic; RNA polymerases