Influenza Virus Infection Induces a Narrow Antibody Response in Children but a Broad Recall Response in Adults

• Published in: mBio Vol. 11; no. 1
• Main Authors: Meade, Philip, Kuan, Guillermina, Strohmeier, Shirin, Maier, Hannah E., Amanat, Fatima, Balmaseda, Angel, Ito, Kimihito, Kirkpatrick, Ericka, Javier, Andres, Gresh, Lionel, Nachbagauer, Raffael, Gordon, Aubree, Krammer, Florian
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 21.01.2020
• Subjects: Adult; Age Factors; Animals; Antibodies, Viral - immunology; Antigens, Viral - immunology; Child; Clinical Science and Epidemiology; Cross Reactions; cross-reactivity; Editor's Pick; heterosubtypic immunity; Humans; Immunoglobulin A - immunology; Immunoglobulin G - immunology; Immunologic Memory; imprinting; influenza; Influenza Vaccines - immunology; influenza virus; Influenza, Human - epidemiology; Influenza, Human - immunology; Influenza, Human - virology; Mice; natural infection; Orthomyxoviridae - classification; Orthomyxoviridae - immunology; Phylogeny; Vaccination; influenza; influenza virus; cross-reactivity; natural infection; imprinting; heterosubtypic immunity

It is known since Thomas Francis, Jr. published his first paper on original antigenic sin in 1960 that the first infection(s) with influenza virus leaves a special immunological imprint which shapes immune responses to future infections with antigenically related influenza virus strains. Imprinting...