Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities

• Published in: Antioxidants & redox signaling Vol. 15; no. 7; p. 1957
• Main Authors: Lubos, Edith, Loscalzo, Joseph, Handy, Diane E
• Format: Journal Article
• Language: English
• Published: United States 01.10.2011
• Subjects: Amino Acid Sequence; Animals; Cardiovascular Diseases - etiology; Cardiovascular Diseases - genetics; Cardiovascular Diseases - therapy; Cell Death; Diabetes Mellitus - etiology; Diabetes Mellitus - genetics; Diabetes Mellitus - therapy; Enzyme Inhibitors - pharmacology; Enzyme Inhibitors - therapeutic use; Gene Expression; Gene Expression Regulation; Genetic Predisposition to Disease; Glutathione Peroxidase - antagonists & inhibitors; Glutathione Peroxidase - chemistry; Glutathione Peroxidase - genetics; Glutathione Peroxidase - metabolism; Glutathione Peroxidase GPX1; Humans; Molecular Sequence Data; Neoplasms - etiology; Neoplasms - genetics; Neoplasms - therapy; Oxidation-Reduction; Oxidative Stress; Polymorphism, Genetic; Protein Conformation; Reactive Oxygen Species - metabolism; Risk Factors; Selenocysteine - chemistry; Selenocysteine - metabolism

Reactive oxygen species, such as superoxide and hydrogen peroxide, are generated in all cells by mitochondrial and enzymatic sources. Left unchecked, these reactive species can cause oxidative damage to DNA, proteins, and membrane lipids. Glutathione peroxidase-1 (GPx-1) is an intracellular antioxid...