A randomized, placebo-controlled trial of ondansetron, metoclopramide, and promethazine in adults

• Published in: The American journal of emergency medicine Vol. 29; no. 3; pp. 247 - 255
• Main Authors: Barrett, Tyler W., DiPersio, David M., Jenkins, Cathy A., Jack, Meg, McCoin, Nicole Streiff, Storrow, Alan B., Singleton, Lori M., Lee, Patricia, Zhou, Chuan, Slovis, Corey M.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.2011; Elsevier; Elsevier Limited
• Subjects: Adult; Analgesics; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Antiemetics - therapeutic use; Bias; Biological and medical sciences; Blood pressure; Chemotherapy; Clinical trial. Drug monitoring; Consent; Double-Blind Method; Drug dosages; Emergency; Emergency medical care; Emergency Service, Hospital; Female; General pharmacology; Humans; Intensive care medicine; Male; Medical sciences; Metoclopramide - adverse effects; Metoclopramide - therapeutic use; Middle Aged; Nausea - drug therapy; Ondansetron - adverse effects; Ondansetron - therapeutic use; Pharmacology. Drug treatments; Promethazine - adverse effects; Promethazine - therapeutic use; Treatment Outcome; Young Adult; Intensive care; Dopamine antagonist; Serotonin antagonist; Promethazine; Phenothiazine derivatives; Antihistaminic; Metoclopramide; Antiallergic; D2 Dopamine receptor; 5-HT3 Serotonine receptor; Benzamide derivatives; H1 Histamine receptor; Antiemetic; Ondansetron; Resuscitation

The objective of the study was to assess whether ondansetron has superior nausea reduction compared with metoclopramide, promethazine, or saline placebo in emergency department (ED) adults. This randomized, placebo-controlled, double-blinded superiority trial was intended to enroll a convenience sam...