Interaction of Manganese-Doped Copper Oxide Nano-Platelets with Cells: Biocompatibility and Anticancer Activity Assessment

Understanding cellular interaction with nanomaterials represents a subject of great interest for the validation of new diagnostic and therapeutic tools. A full characterization of a designed product includes the evaluation of its impact on specific biological systems, including the study of cell beh...

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Published inBiomimetics (Basel, Switzerland) Vol. 10; no. 4; p. 203
Main Authors Pană, Ioan-Ovidiu, Ciorîță, Alexandra, Boca, Sanda, Guțoiu, Simona, Kacso, Irina, Miclăuș, Maria Olimpia, Grad, Oana, Gherman, Ana Maria Raluca, Leostean, Cristian, Suciu, Maria
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 26.03.2025
MDPI
Subjects
Antitumor activity
Aqueous solutions
Biocompatibility
Biomedical engineering
biomimicry
Cancer
Cancer therapies
cancer therapy
Care and treatment
Cell differentiation
cell interaction
Chloride
Copper
Copper oxide
Cuprite
Diagnosis
Drug delivery
Drug resistance
Drug therapy
Electron microscopy
Energy storage
Enzymes
Genetic aspects
Health aspects
Horticultural industry
Infectious diseases
Light scattering
Manganese
manganese-doped copper oxide nanoparticles
Melanoma
Nanoparticles
Nanotechnology
Photoelectron spectroscopy
Platelets
Potash
Potassium
Reactive oxygen species
Side effects
Software
Spectrum analysis
Toxicity
X-ray diffraction
X-ray spectroscopy
Germany
Romania
cancer therapy
manganese-doped copper oxide nanoparticles
biomimicry
biocompatibility
cell interaction
Online AccessGet full text
ISSN2313-7673
2313-7673
DOI10.3390/biomimetics10040203

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Abstract Understanding cellular interaction with nanomaterials represents a subject of great interest for the validation of new diagnostic and therapeutic tools. A full characterization of a designed product includes the evaluation of its impact on specific biological systems, including the study of cell behavior as a response to that particular interaction. Copper and copper-based nanoparticles (CuO NPs) have emerged as valuable building blocks for various biomedical applications such as antibacterial and disinfecting agents for infectious diseases, and the evaluation of the metabolism of food, including the iron required for proteins and enzymes or as drug delivery systems in cancer therapy. In this study, the biological impact of manganese-doped crystalline copper oxide (CuO:Mn) nano-platelets on human normal BJ fibroblasts and human A375 skin melanoma was assessed. The particles were synthesized at room temperature via the hydrothermal method. A complete physicochemical characterization of the materials was performed by employing various techniques including X-ray diffraction, electron microscopy, X-Ray photoelectron spectroscopy, and dynamic light scattering. Morphological investigations revealed a flat structure with nearly straight edges, with sizes spanning in the nanometer range. XRD analysis confirmed the formation of the CuO phase with good crystallinity, while XPS provided insights into the Mn doping. The findings indicate that nano-platelets interact with cells actively by mediating essential molecular processes. The exogenous manganese triggers increased MnSOD production in mitochondria, compensating ROS produced by external stress factors (Cu2+ ions), and mimics the endogenous SODs production, which compensates internal ROS production as it normally results from cell biochemistry. The effect is differentiated in normal cells compared to malignant cells and deserves investigation.
AbstractList Understanding cellular interaction with nanomaterials represents a subject of great interest for the validation of new diagnostic and therapeutic tools. A full characterization of a designed product includes the evaluation of its impact on specific biological systems, including the study of cell behavior as a response to that particular interaction. Copper and copper-based nanoparticles (CuO NPs) have emerged as valuable building blocks for various biomedical applications such as antibacterial and disinfecting agents for infectious diseases, and the evaluation of the metabolism of food, including the iron required for proteins and enzymes or as drug delivery systems in cancer therapy. In this study, the biological impact of manganese-doped crystalline copper oxide (CuO:Mn) nano-platelets on human normal BJ fibroblasts and human A375 skin melanoma was assessed. The particles were synthesized at room temperature via the hydrothermal method. A complete physicochemical characterization of the materials was performed by employing various techniques including X-ray diffraction, electron microscopy, X-Ray photoelectron spectroscopy, and dynamic light scattering. Morphological investigations revealed a flat structure with nearly straight edges, with sizes spanning in the nanometer range. XRD analysis confirmed the formation of the CuO phase with good crystallinity, while XPS provided insights into the Mn doping. The findings indicate that nano-platelets interact with cells actively by mediating essential molecular processes. The exogenous manganese triggers increased MnSOD production in mitochondria, compensating ROS produced by external stress factors (Cu ions), and mimics the endogenous SODs production, which compensates internal ROS production as it normally results from cell biochemistry. The effect is differentiated in normal cells compared to malignant cells and deserves investigation.
Understanding cellular interaction with nanomaterials represents a subject of great interest for the validation of new diagnostic and therapeutic tools. A full characterization of a designed product includes the evaluation of its impact on specific biological systems, including the study of cell behavior as a response to that particular interaction. Copper and copper-based nanoparticles (CuO NPs) have emerged as valuable building blocks for various biomedical applications such as antibacterial and disinfecting agents for infectious diseases, and the evaluation of the metabolism of food, including the iron required for proteins and enzymes or as drug delivery systems in cancer therapy. In this study, the biological impact of manganese-doped crystalline copper oxide (CuO:Mn) nano-platelets on human normal BJ fibroblasts and human A375 skin melanoma was assessed. The particles were synthesized at room temperature via the hydrothermal method. A complete physicochemical characterization of the materials was performed by employing various techniques including X-ray diffraction, electron microscopy, X-Ray photoelectron spectroscopy, and dynamic light scattering. Morphological investigations revealed a flat structure with nearly straight edges, with sizes spanning in the nanometer range. XRD analysis confirmed the formation of the CuO phase with good crystallinity, while XPS provided insights into the Mn doping. The findings indicate that nano-platelets interact with cells actively by mediating essential molecular processes. The exogenous manganese triggers increased MnSOD production in mitochondria, compensating ROS produced by external stress factors (Cu[sup.2+] ions), and mimics the endogenous SODs production, which compensates internal ROS production as it normally results from cell biochemistry. The effect is differentiated in normal cells compared to malignant cells and deserves investigation.
Understanding cellular interaction with nanomaterials represents a subject of great interest for the validation of new diagnostic and therapeutic tools. A full characterization of a designed product includes the evaluation of its impact on specific biological systems, including the study of cell behavior as a response to that particular interaction. Copper and copper-based nanoparticles (CuO NPs) have emerged as valuable building blocks for various biomedical applications such as antibacterial and disinfecting agents for infectious diseases, and the evaluation of the metabolism of food, including the iron required for proteins and enzymes or as drug delivery systems in cancer therapy. In this study, the biological impact of manganese-doped crystalline copper oxide (CuO:Mn) nano-platelets on human normal BJ fibroblasts and human A375 skin melanoma was assessed. The particles were synthesized at room temperature via the hydrothermal method. A complete physicochemical characterization of the materials was performed by employing various techniques including X-ray diffraction, electron microscopy, X-Ray photoelectron spectroscopy, and dynamic light scattering. Morphological investigations revealed a flat structure with nearly straight edges, with sizes spanning in the nanometer range. XRD analysis confirmed the formation of the CuO phase with good crystallinity, while XPS provided insights into the Mn doping. The findings indicate that nano-platelets interact with cells actively by mediating essential molecular processes. The exogenous manganese triggers increased MnSOD production in mitochondria, compensating ROS produced by external stress factors (Cu2+ ions), and mimics the endogenous SODs production, which compensates internal ROS production as it normally results from cell biochemistry. The effect is differentiated in normal cells compared to malignant cells and deserves investigation.
Understanding cellular interaction with nanomaterials represents a subject of great interest for the validation of new diagnostic and therapeutic tools. A full characterization of a designed product includes the evaluation of its impact on specific biological systems, including the study of cell behavior as a response to that particular interaction. Copper and copper-based nanoparticles (CuO NPs) have emerged as valuable building blocks for various biomedical applications such as antibacterial and disinfecting agents for infectious diseases, and the evaluation of the metabolism of food, including the iron required for proteins and enzymes or as drug delivery systems in cancer therapy. In this study, the biological impact of manganese-doped crystalline copper oxide (CuO:Mn) nano-platelets on human normal BJ fibroblasts and human A375 skin melanoma was assessed. The particles were synthesized at room temperature via the hydrothermal method. A complete physicochemical characterization of the materials was performed by employing various techniques including X-ray diffraction, electron microscopy, X-Ray photoelectron spectroscopy, and dynamic light scattering. Morphological investigations revealed a flat structure with nearly straight edges, with sizes spanning in the nanometer range. XRD analysis confirmed the formation of the CuO phase with good crystallinity, while XPS provided insights into the Mn doping. The findings indicate that nano-platelets interact with cells actively by mediating essential molecular processes. The exogenous manganese triggers increased MnSOD production in mitochondria, compensating ROS produced by external stress factors (Cu2+ ions), and mimics the endogenous SODs production, which compensates internal ROS production as it normally results from cell biochemistry. The effect is differentiated in normal cells compared to malignant cells and deserves investigation.Understanding cellular interaction with nanomaterials represents a subject of great interest for the validation of new diagnostic and therapeutic tools. A full characterization of a designed product includes the evaluation of its impact on specific biological systems, including the study of cell behavior as a response to that particular interaction. Copper and copper-based nanoparticles (CuO NPs) have emerged as valuable building blocks for various biomedical applications such as antibacterial and disinfecting agents for infectious diseases, and the evaluation of the metabolism of food, including the iron required for proteins and enzymes or as drug delivery systems in cancer therapy. In this study, the biological impact of manganese-doped crystalline copper oxide (CuO:Mn) nano-platelets on human normal BJ fibroblasts and human A375 skin melanoma was assessed. The particles were synthesized at room temperature via the hydrothermal method. A complete physicochemical characterization of the materials was performed by employing various techniques including X-ray diffraction, electron microscopy, X-Ray photoelectron spectroscopy, and dynamic light scattering. Morphological investigations revealed a flat structure with nearly straight edges, with sizes spanning in the nanometer range. XRD analysis confirmed the formation of the CuO phase with good crystallinity, while XPS provided insights into the Mn doping. The findings indicate that nano-platelets interact with cells actively by mediating essential molecular processes. The exogenous manganese triggers increased MnSOD production in mitochondria, compensating ROS produced by external stress factors (Cu2+ ions), and mimics the endogenous SODs production, which compensates internal ROS production as it normally results from cell biochemistry. The effect is differentiated in normal cells compared to malignant cells and deserves investigation.
Understanding cellular interaction with nanomaterials represents a subject of great interest for the validation of new diagnostic and therapeutic tools. A full characterization of a designed product includes the evaluation of its impact on specific biological systems, including the study of cell behavior as a response to that particular interaction. Copper and copper-based nanoparticles (CuO NPs) have emerged as valuable building blocks for various biomedical applications such as antibacterial and disinfecting agents for infectious diseases, and the evaluation of the metabolism of food, including the iron required for proteins and enzymes or as drug delivery systems in cancer therapy. In this study, the biological impact of manganese-doped crystalline copper oxide (CuO:Mn) nano-platelets on human normal BJ fibroblasts and human A375 skin melanoma was assessed. The particles were synthesized at room temperature via the hydrothermal method. A complete physicochemical characterization of the materials was performed by employing various techniques including X-ray diffraction, electron microscopy, X-Ray photoelectron spectroscopy, and dynamic light scattering. Morphological investigations revealed a flat structure with nearly straight edges, with sizes spanning in the nanometer range. XRD analysis confirmed the formation of the CuO phase with good crystallinity, while XPS provided insights into the Mn doping. The findings indicate that nano-platelets interact with cells actively by mediating essential molecular processes. The exogenous manganese triggers increased MnSOD production in mitochondria, compensating ROS produced by external stress factors (Cu 2+ ions), and mimics the endogenous SODs production, which compensates internal ROS production as it normally results from cell biochemistry. The effect is differentiated in normal cells compared to malignant cells and deserves investigation.
Audience Academic
Author Miclăuș, Maria Olimpia
Grad, Oana
Kacso, Irina
Gherman, Ana Maria Raluca
Leostean, Cristian
Pană, Ioan-Ovidiu
Ciorîță, Alexandra
Boca, Sanda
Suciu, Maria
Guțoiu, Simona
AuthorAffiliation 2 Electron Microscopy Center C. Craciun, Faculty of Biology and Geology, Babeș-Bolyai University, 5-7 Clinicilor Street, 400006 Cluj-Napoca, Romania
1 National Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat Street, 400293 Cluj-Napoca, Romania; ovidiu.pana@itim-cj.ro (I.-O.P.); alexandra.ciorita@ubbcluj.ro (A.C.); simona.gutoiu@itim-cj.ro (S.G.); irina.kacso@itim-cj.ro (I.K.); maria.miclaus@itim-cj.ro (M.O.M.); oana.grad@itim-cj.ro (O.G.); raluca.gherman@itim-cj.ro (A.M.R.G.); cristian.leostean@itim-cj.ro (C.L.); maria.suciu@itim-cj.ro (M.S.)
3 Interdisciplinary Research Institute in Bio-Nano-Sciences, Babeș-Bolyai University, 42 Treboniu Laurian, 400271 Cluj-Napoca, Romania
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Cites_doi 10.1128/AEM.01952-09
10.1016/j.matchemphys.2021.124474
10.1038/nrm2256
10.1007/s11356-019-05345-1
10.1016/j.biotno.2024.06.001
10.1007/s11051-016-3369-2
10.1016/j.toxlet.2013.07.019
10.1016/j.actbio.2017.07.006
10.1093/mutage/get014
10.3390/nano11051084
10.1016/j.jallcom.2014.09.085
10.1002/adma.200800243
10.1038/s41598-022-25483-w
10.1038/s41467-020-16544-7
10.1038/nrd4002
10.1007/s10534-007-9098-3
10.1007/s10854-022-09540-8
10.3389/fmats.2022.857385
10.1016/j.jallcom.2013.07.194
10.3390/coatings13061014
10.3390/cancers11070955
10.1021/acsnano.9b05836
10.3390/polym13132123
10.1016/S0040-6090(03)00940-4
10.1039/C4TB00196F
10.3390/toxins14090609
10.1007/s00432-024-05641-5
10.1016/j.cbi.2005.12.009
10.1088/0957-4484/26/5/055101
10.1063/1.1416478
10.1038/s41598-023-28958-6
10.1002/anie.201805664
10.1016/j.molstruc.2021.131459
10.1016/j.physleta.2012.05.042
10.3390/molecules29225461
10.1021/acs.chemmater.5b03128
10.7326/0003-4819-107-4-526
10.1128/mbio.03251-21
10.3390/jpm11080771
10.3390/nano11020451
10.1038/s41598-022-20360-y
10.1007/s11051-011-0313-3
10.1016/j.mssp.2022.106644
10.1002/adhm.201701156
10.1021/acsnano.8b01893
10.1016/j.actbio.2020.06.023
10.1021/tx3002093
10.1021/acs.bioconjchem.6b00437
10.1021/la404091z
10.1016/j.antiviral.2015.06.016
10.3762/bjnano.13.40
10.1039/C5EN00271K
10.1002/anie.201712027
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Keywords cancer therapy
manganese-doped copper oxide nanoparticles
biomimicry
biocompatibility
cell interaction
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References ref_50
Hans (ref_30) 2013; 29
Balamurugan (ref_23) 2001; 79
Pop (ref_41) 2013; 581
Nakamura (ref_54) 2016; 27
ref_11
ref_55
Tang (ref_16) 2019; 58
ref_53
Marica (ref_5) 2022; 13
Bayansal (ref_21) 2014; 619
Bahoosh (ref_24) 2012; 376
Falamas (ref_4) 2022; 145
Cross (ref_10) 1987; 107
Ganea (ref_39) 2022; 1248
Lin (ref_17) 2018; 57
Urandur (ref_52) 2020; 113
Fu (ref_18) 2019; 13
Wang (ref_15) 2018; 7
Taratula (ref_13) 2015; 27
Wongrakpanich (ref_46) 2016; 3
Valko (ref_12) 2006; 160
ref_26
Armelao (ref_22) 2003; 442
Fabbrizi (ref_48) 2013; 28
Toledano (ref_9) 2007; 8
Stefan (ref_1) 2016; 18
Koiri (ref_43) 2008; 21
Jing (ref_14) 2008; 20
Leostean (ref_42) 2011; 13
ref_36
ref_35
Liu (ref_19) 2018; 12
Devaraji (ref_34) 2024; 5
Hassan (ref_28) 2014; 2
Abdolmaleki (ref_32) 2024; 150
ref_38
ref_37
Evans (ref_33) 2015; 121
Tootoonchi (ref_51) 2017; 59
Nie (ref_20) 2022; 9
Santo (ref_29) 2010; 76
Liu (ref_31) 2020; 11
Wang (ref_47) 2012; 25
ref_45
Gorrini (ref_8) 2013; 12
Zuily (ref_27) 2022; 13
ref_40
ref_3
Moschini (ref_44) 2013; 222
Stefan (ref_2) 2021; 264
Sultana (ref_7) 2015; 26
ref_49
Ammar (ref_6) 2023; 34
Husain (ref_25) 2019; 26
References_xml – volume: 76
  start-page: 1341
  year: 2010
  ident: ref_29
  article-title: Isolation and Characterization of Bacteria Resistant to Metallic Copper Surfaces
  publication-title: Appl. Environ. Microbiol.
  doi: 10.1128/AEM.01952-09
– volume: 264
  start-page: 124474
  year: 2021
  ident: ref_2
  article-title: Synthesis and Characterization of Fe3O4–ZnS:Mn Nanocomposites for Biomedical Applications
  publication-title: Mater. Chem. Phys.
  doi: 10.1016/j.matchemphys.2021.124474
– volume: 8
  start-page: 813
  year: 2007
  ident: ref_9
  article-title: ROS as Signalling Molecules: Mechanisms That Generate Specificity in ROS Homeostasis
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm2256
– volume: 26
  start-page: 20654
  year: 2019
  ident: ref_25
  article-title: Copper(II) generates ROS and RNS, impairs antioxidant system and damages membrane and DNA in human blood cells
  publication-title: Environ. Sci. Pollut. Res.
  doi: 10.1007/s11356-019-05345-1
– volume: 5
  start-page: 80
  year: 2024
  ident: ref_34
  article-title: The potential of copper oxide nanoparticles in nanomedicine: A comprehensive review
  publication-title: Biotechnol. Notes.
  doi: 10.1016/j.biotno.2024.06.001
– volume: 18
  start-page: 59
  year: 2016
  ident: ref_1
  article-title: Interface Charge Transfer Process in ZnO:Mn/ZnS Nanocomposites
  publication-title: J. Nanoparticle Res.
  doi: 10.1007/s11051-016-3369-2
– volume: 222
  start-page: 102
  year: 2013
  ident: ref_44
  article-title: The Modality of Cell-Particle Interactions Drives the Toxicity of Nanosized CuO and TiO2 in Human Alveolar Epithelial Cells
  publication-title: Toxicol. Lett.
  doi: 10.1016/j.toxlet.2013.07.019
– volume: 59
  start-page: 327
  year: 2017
  ident: ref_51
  article-title: Manganese Oxide Particles as Cytoprotective, Oxygen Generating Agents
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2017.07.006
– volume: 28
  start-page: 287
  year: 2013
  ident: ref_48
  article-title: Multiple Cytotoxic and Genotoxic Effects Induced in Vitro by Differently Shaped Copper Oxide Nanomaterials
  publication-title: Mutagenesis
  doi: 10.1093/mutage/get014
– ident: ref_49
  doi: 10.3390/nano11051084
– volume: 619
  start-page: 378
  year: 2014
  ident: ref_21
  article-title: CuO Nanostructures Grown by the SILAR Method: Influence of Pb-Doping on the Morphological, Structural and Optical Properties
  publication-title: J. Alloys Compd.
  doi: 10.1016/j.jallcom.2014.09.085
– volume: 20
  start-page: 4547
  year: 2008
  ident: ref_14
  article-title: Fabrication and Gas-Sensing Properties of Porous ZnO Nanoplates
  publication-title: Adv. Mater.
  doi: 10.1002/adma.200800243
– ident: ref_50
  doi: 10.1038/s41598-022-25483-w
– volume: 11
  start-page: 2788
  year: 2020
  ident: ref_31
  article-title: Ultrasmall Copper-Based Nanoparticles for Reactive Oxygen Species Scavenging and Alleviation of Inflammation Related Diseases
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-16544-7
– volume: 12
  start-page: 931
  year: 2013
  ident: ref_8
  article-title: Modulation of Oxidative Stress as an Anticancer Strategy
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd4002
– volume: 21
  start-page: 117
  year: 2008
  ident: ref_43
  article-title: Metal Cu(II) and Zn(II) bipyridyls as inhibitors of lactate dehydrogenase
  publication-title: Biometals
  doi: 10.1007/s10534-007-9098-3
– volume: 34
  start-page: 98
  year: 2023
  ident: ref_6
  article-title: Characterization of Defect Structures in Nanoscaled W-Doped TiO 2 Tested as Supercapacitor Electrode Materials
  publication-title: J. Mater. Sci. Mater. Electron.
  doi: 10.1007/s10854-022-09540-8
– volume: 9
  start-page: 1
  year: 2022
  ident: ref_20
  article-title: Research Advance in Manganese Nanoparticles in Cancer Diagnosis and Therapy
  publication-title: Front. Mater.
  doi: 10.3389/fmats.2022.857385
– volume: 581
  start-page: 821
  year: 2013
  ident: ref_41
  article-title: The Influence of Milling and Annealing on the Structural and Magnetic Behavior of Nd2Fe14B/α-Fe Magnetic Nanocomposite
  publication-title: J. Alloys Compd.
  doi: 10.1016/j.jallcom.2013.07.194
– ident: ref_37
  doi: 10.3390/coatings13061014
– ident: ref_11
  doi: 10.3390/cancers11070955
– volume: 13
  start-page: 13985
  year: 2019
  ident: ref_18
  article-title: Biodegradable Manganese-Doped Calcium Phosphate Nanotheranostics for Traceable Cascade Reaction-Enhanced Anti-Tumor Therapy
  publication-title: ACS Nano
  doi: 10.1021/acsnano.9b05836
– ident: ref_3
  doi: 10.3390/polym13132123
– ident: ref_38
– volume: 442
  start-page: 48
  year: 2003
  ident: ref_22
  article-title: A Sol-Gel Approach to Nanophasic Copper Oxide Thin Films
  publication-title: Thin Solid Film.
  doi: 10.1016/S0040-6090(03)00940-4
– volume: 2
  start-page: 2855
  year: 2014
  ident: ref_28
  article-title: Antimicrobial Activity of Copper and Copper(I) Oxide Thin Films Deposited via Aerosol-Assisted CVD
  publication-title: J. Mater. Chem. B
  doi: 10.1039/C4TB00196F
– ident: ref_55
  doi: 10.3390/toxins14090609
– volume: 150
  start-page: 213
  year: 2024
  ident: ref_32
  article-title: Unveiling the promising anticancer effect of copper-based compounds: A comprehensive review
  publication-title: J. Cancer Res. Clin. Oncol.
  doi: 10.1007/s00432-024-05641-5
– volume: 160
  start-page: 1
  year: 2006
  ident: ref_12
  article-title: Mini-Review Free Radicals, Metals and Antioxidants in Oxidative Stress-Induced Cancer
  publication-title: Chem. Biol. Interact.
  doi: 10.1016/j.cbi.2005.12.009
– volume: 26
  start-page: 55101
  year: 2015
  ident: ref_7
  article-title: Comparative Toxicity Evaluation of Flower-Shaped and Spherical Gold Nanoparticles on Human Endothelial Cells
  publication-title: Nanotechnology
  doi: 10.1088/0957-4484/26/5/055101
– volume: 79
  start-page: 3176
  year: 2001
  ident: ref_23
  article-title: Surface-Modified CuO Layer in Size-Stabilized Single-Phase Cu2O Nanoparticles
  publication-title: Appl. Phys. Lett.
  doi: 10.1063/1.1416478
– ident: ref_45
  doi: 10.1038/s41598-023-28958-6
– volume: 58
  start-page: 946
  year: 2019
  ident: ref_16
  article-title: Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reactions
  publication-title: Angew. Chemie Int. Ed.
  doi: 10.1002/anie.201805664
– volume: 1248
  start-page: 131459
  year: 2022
  ident: ref_39
  article-title: Responsiveness assessment of cell cultures exposed to poly(tartaric acid) and its corresponding magnetic nanostructures
  publication-title: J. Mol. Struct.
  doi: 10.1016/j.molstruc.2021.131459
– volume: 376
  start-page: 2252
  year: 2012
  ident: ref_24
  article-title: Theory of Phonon Properties in Doped and Undoped CuO Nanoparticles
  publication-title: Phys. Lett. A
  doi: 10.1016/j.physleta.2012.05.042
– ident: ref_26
  doi: 10.3390/molecules29225461
– ident: ref_40
– volume: 27
  start-page: 6155
  year: 2015
  ident: ref_13
  article-title: Naphthalocyanine-Based Biodegradable Polymeric Nanoparticles for Image-Guided Combinatorial Phototherapy
  publication-title: Chem. Mater.
  doi: 10.1021/acs.chemmater.5b03128
– volume: 107
  start-page: 526
  year: 1987
  ident: ref_10
  article-title: Oxygen Radicals and Human Disease
  publication-title: Ann. Intern. Med.
  doi: 10.7326/0003-4819-107-4-526
– volume: 13
  start-page: e03251-21
  year: 2022
  ident: ref_27
  article-title: Copper Induces Protein Aggregation, a Toxic Process Compensated by Molecular Chaperones
  publication-title: mBio
  doi: 10.1128/mbio.03251-21
– ident: ref_53
  doi: 10.3390/jpm11080771
– ident: ref_36
  doi: 10.3390/nano11020451
– ident: ref_35
  doi: 10.1038/s41598-022-20360-y
– volume: 13
  start-page: 6181
  year: 2011
  ident: ref_42
  article-title: Comparative Study of Core-Shell Iron/Iron Oxide Gold Covered Magnetic Nanoparticles Obtained in Different Conditions
  publication-title: J. Nanoparticle Res.
  doi: 10.1007/s11051-011-0313-3
– volume: 145
  start-page: 106644
  year: 2022
  ident: ref_4
  article-title: Size-Dependent Spectroscopic Insight into the Steady-State and Time-Resolved Optical Properties of ZnO Photocatalysts
  publication-title: Mater. Sci. Semicond. Process.
  doi: 10.1016/j.mssp.2022.106644
– volume: 7
  start-page: e1701156
  year: 2018
  ident: ref_15
  article-title: Tumor Microenvironment-Enabled Nanotherapy
  publication-title: Adv. Healthc. Mater.
  doi: 10.1002/adhm.201701156
– volume: 12
  start-page: 4886
  year: 2018
  ident: ref_19
  article-title: All-in-One Theranostic Nanoagent with Enhanced Reactive Oxygen Species Generation and Modulating Tumor Microenvironment Ability for Effective Tumor Eradication
  publication-title: ACS Nano
  doi: 10.1021/acsnano.8b01893
– volume: 113
  start-page: 522
  year: 2020
  ident: ref_52
  article-title: Theranostic Lyotropic Liquid Crystalline Nanostructures for Selective Breast Cancer Imaging and Therapy
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2020.06.023
– volume: 25
  start-page: 1512
  year: 2012
  ident: ref_47
  article-title: CuO Nanoparticle Interaction with Human Epithelial Cells: Cellular Uptake, Location, Export, and Genotoxicity
  publication-title: Chem. Res. Toxicol.
  doi: 10.1021/tx3002093
– volume: 27
  start-page: 2225
  year: 2016
  ident: ref_54
  article-title: Nanodrug Delivery: Is the Enhanced Permeability and Retention Effect Sufficient for Curing Cancer?
  publication-title: Bioconjug. Chem.
  doi: 10.1021/acs.bioconjchem.6b00437
– volume: 29
  start-page: 16160
  year: 2013
  ident: ref_30
  article-title: Role of Copper Oxides in Contact Killing of Bacteria
  publication-title: Langmuir
  doi: 10.1021/la404091z
– volume: 121
  start-page: 31
  year: 2015
  ident: ref_33
  article-title: Benzimidazole analogs inhibit respiratory syncytial virus G protein function
  publication-title: Antiviral Res.
  doi: 10.1016/j.antiviral.2015.06.016
– volume: 13
  start-page: 472
  year: 2022
  ident: ref_5
  article-title: Zinc Oxide Nanostructures for Fluorescence and Raman Signal Enhancement: A Review
  publication-title: Beilstein J. Nanotechnol.
  doi: 10.3762/bjnano.13.40
– volume: 3
  start-page: 365
  year: 2016
  ident: ref_46
  article-title: Size-Dependent Cytotoxicity of Copper Oxide Nanoparticles in Lung Epithelial Cells
  publication-title: Environ. Sci. Nano
  doi: 10.1039/C5EN00271K
– volume: 57
  start-page: 4902
  year: 2018
  ident: ref_17
  article-title: Simultaneous Fenton-like Ion Delivery and Glutathione Depletion by MnO2-Based Nanoagent to Enhance Chemodynamic Therapy
  publication-title: Angew. Chemie Int. Ed.
  doi: 10.1002/anie.201712027
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Snippet Understanding cellular interaction with nanomaterials represents a subject of great interest for the validation of new diagnostic and therapeutic tools. A full...
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SubjectTerms Antitumor activity
Aqueous solutions
Biocompatibility
Biomedical engineering
biomimicry
Cancer
Cancer therapies
cancer therapy
Care and treatment
Cell differentiation
cell interaction
Chloride
Copper
Copper oxide
Cuprite
Diagnosis
Drug delivery
Drug resistance
Drug therapy
Electron microscopy
Energy storage
Enzymes
Genetic aspects
Health aspects
Horticultural industry
Infectious diseases
Light scattering
Manganese
manganese-doped copper oxide nanoparticles
Melanoma
Nanoparticles
Nanotechnology
Photoelectron spectroscopy
Platelets
Potash
Potassium
Reactive oxygen species
Side effects
Software
Spectrum analysis
Toxicity
X-ray diffraction
X-ray spectroscopy
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Title Interaction of Manganese-Doped Copper Oxide Nano-Platelets with Cells: Biocompatibility and Anticancer Activity Assessment
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