Novel ex vivo disease model for extramammary Paget’s disease using the cancer tissue-originated spheroid method

• Published in: Journal of dermatological science Vol. 99; no. 3; pp. 185 - 192
• Main Authors: Arita, Takahiro, Kondo, Jumpei, Kaneko, Yuka, Tsutsumi, Miho, Kanemaru, Mai, Matsui, Mari, Arakawa, Yukiyasu, Katoh, Norito, Inoue, Masahiro, Asai, Jun
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.09.2020
• Subjects: Chemosensitivity assay; CTOS; Ex vivo disease model; Extramammary Paget’s disease; HRG–HER3 signaling; 5FU; EGF; PDX; CK; HRG–HER3 signaling; IGF; CTOS; bFGF; Chemosensitivity assay; DMEM; GFR; TGF; HER; PI3K; FBS; Extramammary Paget’s disease; EMPD; HRG; RPMI; Ex vivo disease model; GF

•Effective EMPD treatments are lacking partly because of no current ex vivo models.•We firstly established CTOSs, an ex vivo model of EMPD.•CTOSs retain the characteristics of original tumors.•CTOSs are useful for investigating the pathogenesis and treatments of EMPD. Extramammary Paget’s disease (E...