Reconsideration of the Role of Regulatory T Cells during Pregnancy: Differential Characteristics of Regulatory T Cells between the Maternal-Fetal Interface and Peripheral Sites and between Early and Late Pregnancy

• Published in: Medical principles and practice Vol. 31; no. 5; pp. 403 - 414
• Main Author: Saito, Shigeru
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.12.2022
• Subjects: Abortion, Spontaneous; Antigens; Chemokines; Cytokines; Cytotoxicity; Extracellular vesicles; Female; Females; Fetus; Fetuses; Humans; Immune Tolerance; Lymphatic system; Lymphocytes; Males; Miscarriage; Placenta; Plasma; Pre-Eclampsia - metabolism; Preeclampsia; Pregnancy; Review; Sexual intercourse; Sperm; T-Lymphocytes, Regulatory - metabolism; Uterus; Veins & arteries; Peripheral regulatory T cells; Thymus-derived regulatory T cells; Miscarriage; Preeclampsia; Paternal antigen-specific regulatory T cells

Regulatory T (Treg) cells play an important role in implantation of the embryo and maintenance of pregnancy after allogeneic mating. Implantation failure, miscarriage, and preeclampsia are associated with decreased numbers of Treg cells or with dysfunctional Treg cells. Treg cells are classified int...