Estimation of latamoxef (moxalactam) dosage regimens against β-lactamase–producing Enterobacterales in dogs: a pharmacokinetic and pharmacodynamic analysis using Monte Carlo simulation

• Published in: Journal of Veterinary Medical Science Vol. 86; no. 8; pp. 841 - 846
• Main Authors: KUSUMOTO, Mizuki, NARITA, Haruka, MOTEGI, Tomoki, HARADA, Kazuki
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 2024; Japan Science and Technology Agency; The Japanese Society of Veterinary Science
• Subjects: Bacteriostats; Carbapenems; Clinical trials; dog; Dosage; Drug dosages; Enterobacterales; extended-spectrum β-lactamase-producing Enterobacterales; Internal Medicine; latamoxef; Minimum inhibitory concentration; Monte Carlo simulation; Moxalactam; Pharmacodynamics; pharmacokinetic/pharmacodynamic approach; Pharmacokinetics; Veterinary medicine; β Lactamase; extended-spectrum β-lactamase-producing Enterobacterales; latamoxef; pharmacokinetic/pharmacodynamic approach; dog; Monte Carlo simulation

One of the most significant research areas in veterinary medicine is the search for carbapenem substitutes for the treatment of extended-spectrum β-lactamase (ESBL)-producing Enterobacterales (ESBL-E). This study applied a pharmacokinetic/pharmacodynamic (PK/PD) strategy in validating optimal latamo...