Impact of Imprinted Immunity Induced by mRNA Vaccination in an Experimental Animal Model

• Published in: The Journal of infectious diseases Vol. 228; no. 8; pp. 1060 - 1065
• Main Authors: Fujita, Shigeru, Uriu, Keiya, Pan, Lin, Nao, Naganori, Tabata, Koshiro, Kishimoto, Mai, Itakura, Yukari, Sawa, Hirofumi, Kida, Izumi, Tamura, Tomokazu, Fukuhara, Takasuke, Ito, Jumpei, Matsuno, Keita, Sato, Kei
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 18.10.2023
• Subjects: Animal models; Antiviral drugs; Brief Report; Coronaviruses; Humoral immunity; Immunity; mRNA; Nanoparticles; Severe acute respiratory syndrome coronavirus 2; Vaccines; SARS-CoV-2; omicron; imprinted immunity; mRNA vaccine; Omicron

Abstract The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants has led to concerns that ancestral SARS-CoV-2-based vaccines may not be effective against newly emerging Omicron subvariants. The concept of “imprinted immunity” suggests that individuals vaccinat...