Determination of optimal loading and maintenance doses for continuous infusion of vancomycin in critically ill patients: Population pharmacokinetic modelling and simulations for improved dosing schemes

• Published in: International journal of antimicrobial agents Vol. 54; no. 6; pp. 702 - 708
• Main Authors: Vu, Dinh H., Nguyen, Duy A., Delattre, Isabelle K., Ho, Trong T., Do, Hong G., Pham, Hong N., Dao, Xuan C., Tran, Nhan T., Nguyen, Gia B., Van Bambeke, Françoise, Tulkens, Paul M., Nguyen, Hoang A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2019
• Subjects: Adult; Aged; allometry; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacokinetics; blood serum; Computer Simulation; Continuous infusion; creatinine; Critical Illness; Critically ill; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Monitoring; drugs; Enterococcus - drug effects; Female; hospitals; Humans; Loading dose; Maintenance dose; Male; Microbial Sensitivity Tests; Middle Aged; Models, Biological; monitoring; Monte Carlo Method; nephrotoxicity; patients; pharmacokinetics; renal clearance; Staphylococcus aureus - drug effects; Vancomycin; Vancomycin - administration & dosage; Vancomycin - pharmacokinetics; Vietnam; Vietnam; Maintenance dose; Loading dose; Vancomycin; Continuous infusion; Critically ill

•Optimal vancomycin dosing in critically ill patients is still uncertain.•Population pharmacokinetics and simulations were performed using 274 samples from 55 intensive care unit patients.•A 25 mg/kg loading dose (based on distribution volume of ca. 1 L/kg) was optimal.•A daily maintenance dose of 1...