Determination of optimal loading and maintenance doses for continuous infusion of vancomycin in critically ill patients: Population pharmacokinetic modelling and simulations for improved dosing schemes - Vu, Dinh H.; Nguyen, Duy A.; Delattre, Isabelle K.; Ho, Trong T.; Do, Hong G.; Pham, Hong N.; Dao, Xuan C.; Tran, Nhan T.; Nguyen, Gia B.; Van Bambeke, Françoise; Tulkens, Paul M.; Nguyen, Hoang A. (International journal of antimicrobial agents, 2019)
Keywords: Adult; Aged; allometry; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacokinetics; blood serum; Computer Simulation; Continuous infusion; creatinine; Critical Illness; Critically ill; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Monitoring; drugs; Enterococcus - drug effects; Female; hospitals; Humans; Loading dose; Maintenance dose; Male; Microbial Sensitivity Tests; Middle Aged; Models, Biological; monitoring; Monte Carlo Method; nephrotoxicity; patients; pharmacokinetics; renal clearance; Staphylococcus aureus - drug effects; Vancomycin; Vancomycin - administration & dosage; Vancomycin - pharmacokinetics; Vietnam; Vietnam; Maintenance dose; Loading dose; Vancomycin; Continuous infusion; Critically ill