Striatal dopamine transporter and receptor availability correlate with relative cerebral blood flow measured with [11C]PE2I, [18F]FE-PE2I and [11C]raclopride PET in healthy individuals

• Published in: Journal of cerebral blood flow and metabolism Vol. 43; no. 7; pp. 1206 - 1215
• Main Authors: Jonasson, My, Frick, Andreas, Fazio, Patrik, Hjorth, Olof, Danfors, Torsten, Axelsson, Jan, Appel, Lieuwe, Furmark, Tomas, Varrone, Andrea, Lubberink, Mark
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.07.2023
• Subjects: Binding potential; Cerebrovascular Circulation; Dopamine; Dopamine Plasma Membrane Transport Proteins; dopamine system; Humans; kinetic modelling; Original; PET; Positron-Emission Tomography - methods; Raclopride; relative cerebral blood flow; Retrospective Studies; Binding potential; kinetic modelling; dopamine system; PET; relative cerebral blood flow

The aim of this retrospective study was to investigate relationships between relative cerebral blood flow and striatal dopamine transporter and dopamine D2/3 availability in healthy subjects. The data comprised dynamic PET scans with two dopamine transporter tracers [11C]PE2I (n = 20) and [18F]FE-PE...