Chronic treatment with a tryptophan-rich protein hydrolysate improves emotional processing, mental energy levels and reaction time in middle-aged women

• Published in: British journal of nutrition Vol. 113; no. 2; pp. 350 - 365
• Main Authors: Mohajeri, M. H., Wittwer, J., Vargas, K., Hogan, E., Holmes, A., Rogers, P. J., Goralczyk, R., Gibson, E. L.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 28.01.2015
• Subjects: Aged; Amino acids; Antidepressive Agents - adverse effects; Antidepressive Agents - blood; Antidepressive Agents - metabolism; Antidepressive Agents - therapeutic use; Behaviour, Appetite and Obesity; Beverages; bioavailability; brain; cognition; Cognition & reasoning; Cognitive ability; Cognitive Dysfunction - blood; Cognitive Dysfunction - metabolism; Cognitive Dysfunction - prevention & control; Cohort Studies; Depression - blood; Depression - metabolism; Depression - prevention & control; Dietary supplements; Dietary Supplements - adverse effects; Double-Blind Method; Egg Proteins, Dietary - adverse effects; Egg Proteins, Dietary - metabolism; Egg Proteins, Dietary - therapeutic use; eggs; Emotional disorders; emotions; energy; Energy Metabolism; essential amino acids; Female; Humans; Mental Fatigue - blood; Mental Fatigue - metabolism; Mental Fatigue - prevention & control; Middle Aged; Nootropic Agents - adverse effects; Nootropic Agents - blood; Nootropic Agents - metabolism; Nootropic Agents - therapeutic use; placebos; protein hydrolysates; Protein Hydrolysates - adverse effects; Protein Hydrolysates - metabolism; Protein Hydrolysates - therapeutic use; Psychiatric Status Rating Scales; Reaction Time; serotonin; Serotonin Agents - adverse effects; Serotonin Agents - blood; Serotonin Agents - metabolism; Serotonin Agents - therapeutic use; sleep; Sleep Wake Disorders - blood; Sleep Wake Disorders - metabolism; Sleep Wake Disorders - prevention & control; Stress, Psychological - blood; Stress, Psychological - metabolism; Stress, Psychological - prevention & control; tryptophan; Tryptophan - adverse effects; Tryptophan - blood; Tryptophan - metabolism; Tryptophan - therapeutic use; women; Well-being; Serotonin; LumiVida; Tryptophan; Depression; Cognition; Emotion

Common pharmacological treatments of mood disorders aim to modulate serotonergic neurotransmission and enhance serotonin levels in the brain. Brain serotonin levels are dependent on the availability of its food-derived precursor essential amino acid tryptophan (Trp). We tested the hypothesis that de...