Differential involvement of hypothalamic vasopressin neurons in multiple system atrophy

• Published in: Brain (London, England : 1878) Vol. 129; no. 10; pp. 2688 - 2696
• Main Authors: Benarroch, Eduardo E., Schmeichel, Ann M., Sandroni, Paola, Low, Phillip A., Parisi, Joseph E.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.10.2006; Oxford Publishing Limited (England)
• Subjects: Aged; Aged, 80 and over; arginine vasopressin; Biological and medical sciences; Case-Control Studies; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Female; Humans; Hypothalamus, Anterior - chemistry; Hypothalamus, Anterior - pathology; Image Processing, Computer-Assisted; Immunohistochemistry - methods; Male; Medical sciences; Middle Aged; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Multiple System Atrophy - metabolism; Multiple System Atrophy - pathology; Neurology; Neurons - chemistry; Neurons - pathology; Paraventricular Hypothalamic Nucleus - chemistry; paraventricular nucleus; suprachiasmatic nucleus; Suprachiasmatic Nucleus - chemistry; supraoptic nucleus; Supraoptic Nucleus - chemistry; Tyrosine 3-Monooxygenase - analysis; tyrosine hydroxylase; Vasopressins - analysis; Suprachiasmatic nucleus; Nervous system diseases; Enzyme; Central nervous system; Hypothalamus; Paraventricular nucleus; Tyrosine 3-monooxygenase; Neuropeptide; Vasopressin; Encephalon; tyrosine hydroxylase; arginine vasopressin; Neuron; Arginine; Neurohypophyseal hormone; Multiple system atrophy; Oxidoreductases; Supraoptic nucleus

We sought to determine whether there is differential involvement of different groups of hypothalamic arginine-vasopressin (AVP) synthesizing neurons in multiple system atrophy (MSA). Hypothalamus was obtained from five subjects with clinical diagnosis of MSA confirmed neuropathologically and five ag...