Measuring the Forces Involved in Polyvalent Adhesion of Uropathogenic Escherichia coli to Mannose-Presenting Surfaces

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 97; no. 24; pp. 13092 - 13096
• Main Authors: Liang, Michael N., Smith, Stephen P., Metallo, Steven J., Choi, Insung S., Prentiss, Mara, Whitesides, George M.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences of the United States of America 21.11.2000; National Acad Sciences; National Academy of Sciences; The National Academy of Sciences
• Subjects: adhesins; Adhesion; Antibiotics; Bacteria; Bacterial adhesion; Bacterial Adhesion - physiology; Biological Sciences; E coli; Epithelial Cells - microbiology; Escherichia coli; Escherichia coli - pathogenicity; Escherichia coli - physiology; Escherichia coli - ultrastructure; Humans; Laser power; Ligands; Mannose; Microorganisms; Microscopy, Electron; Models, Biological; Molecular interactions; Molecules; Pyelonephritis - microbiology; Receptors; Thiols; Tweezers

Mechanisms of bacterial pathogenesis have become an increasingly important subject as pathogens have become increasingly resistant to current antibiotics. The adhesion of microorganisms to the surface of host tissue is often a first step in pathogenesis and is a plausible target for new antiinfectiv...