Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

• Published in: Cell Vol. 163; no. 7; pp. 1663 - 1677
• Main Authors: Paul, Franziska, Arkin, Ya’ara, Giladi, Amir, Jaitin, Diego Adhemar, Kenigsberg, Ephraim, Keren-Shaul, Hadas, Winter, Deborah, Lara-Astiaso, David, Gury, Meital, Weiner, Assaf, David, Eyal, Cohen, Nadav, Lauridsen, Felicia Kathrine Bratt, Haas, Simon, Schlitzer, Andreas, Mildner, Alexander, Ginhoux, Florent, Jung, Steffen, Trumpp, Andreas, Porse, Bo Torben, Tanay, Amos, Amit, Ido
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 17.12.2015
• Subjects: Animals; Bone Marrow Transplantation; CCAAT-Enhancer-Binding Proteins - genetics; Gene Knockout Techniques; Hematopoiesis; High-Throughput Nucleotide Sequencing; Mice; Mice, Inbred C57BL; Myeloid Progenitor Cells - cytology; Myeloid Progenitor Cells - metabolism; Sequence Analysis, RNA; Single-Cell Analysis; Transcription Factors - metabolism; Transcriptome

Within the bone marrow, stem cells differentiate and give rise to diverse blood cell types and functions. Currently, hematopoietic progenitors are defined using surface markers combined with functional assays that are not directly linked with in vivo differentiation potential or gene regulatory mech...