Prednisolone induces the Wnt signalling pathway in 3T3-L1 adipocytes

• Published in: Archives of physiology and biochemistry Vol. 119; no. 2; pp. 52 - 64
• Main Authors: Fleuren, Wilco W. M., Linssen, Margot M. L., Toonen, Erik J. M., van der Zon, Gerard C. M., Guigas, Bruno, de Vlieg, Jacob, Dokter, Wim H. A., Ouwens, D. Margriet, Alkema, Wynand
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.05.2013; Taylor & Francis
• Subjects: 3T3-L1 Cells; Adipocytes - drug effects; Adipocytes - metabolism; Adipokines - genetics; Animals; Deoxyglucose - metabolism; Gene Expression - drug effects; Gene profiling; glucocorticoids; Glucocorticoids - adverse effects; Glucocorticoids - pharmacology; Immunity - drug effects; Insulin - pharmacology; Insulin Resistance; metabolic dysfunction; Mice; Original; Prednisolone - adverse effects; Prednisolone - pharmacology; Signal Transduction - drug effects; Tissue Array Analysis; Transcriptome - drug effects; Wnt Signaling Pathway - drug effects; Wnt Signaling Pathway - genetics

Abstract Synthetic glucocorticoids are potent anti-inflammatory drugs but show dose-dependent metabolic side effects such as the development of insulin resistance and obesity. The precise mechanisms involved in these glucocorticoid-induced side effects, and especially the participation of adipose ti...