Discoidin domain receptor 1 gene variants are associated with decreased white matter fractional anisotropy and decreased processing speed in schizophrenia

• Published in: Journal of psychiatric research Vol. 110; pp. 74 - 82
• Main Authors: Gas, Cinta, Canales-Rodríguez, Erick Jorge, Radua, Joaquim, Abasolo, Nerea, Cortés, Maria José, Salvadó, Ester, Muntané, Gerard, Alemán-Gómez, Yasser, Julià, Toni, Marsal, Sara, Sanjuan, Julio, Guitart, Miriam, Costas, Javier, Martorell, Lourdes, Pomarol-Clotet, Edith, Vilella, Elisabet
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2019
• Subjects: Adult; Case-Control Studies; Cognition; Cognitive Dysfunction - physiopathology; DDR1; Discoidin Domain Receptor 1 - genetics; Female; Genetics; Humans; Imaging; Magnetic Resonance Imaging; Male; Middle Aged; Myelin; Polymorphism, Single Nucleotide; Schizophrenia - genetics; Schizophrenia - pathology; Schizophrenia - physiopathology; Spain; White Matter - diagnostic imaging; White Matter - pathology; Spain; DDR1; Genetics; Cognition; Myelin; Imaging

DDR1 has been linked to schizophrenia (SZ) and myelination. Here, we tested whether DDR1 variants in people at risk for SZ influence white matter (WM) structural variations and cognitive processing speed (PS). First, following a case-control design (Study 1), SZ patients (N = 1193) and controls (N =...