Investigating the Pulmonary Host Response of Acinetobacter baumannii Infection-Associated Pneumonia by Metagenomic Next-Generation Sequencing

• Published in: Biomedicines Vol. 13; no. 1; p. 142
• Main Authors: Chou, Mu-Jung, Cheng, Chih-Hung, Wang, Hui-Ching, Tsai, Ming-Ju, Sheu, Chau-Chyun, Chang, Wei-An
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.01.2025; MDPI
• Subjects: Acinetobacter baumannii; Actin; Antimicrobial resistance; Bacteria; Bacterial infections; Bacterial pneumonia; Bioinformatics; Bronchus; Causes of; Cytoskeleton; Drug resistance; Enzymes; Ferroptosis; Gene expression; Genes; Genetic aspects; Health aspects; Host-bacteria relationships; immune; Immune response; Infections; Information processing; Lavage; Lungs; Metagenomics; Metallo-β-lactamase; mNGS; NDM; Next-generation sequencing; Pathogens; Patients; Physiological aspects; Pneumonia; pulmonary host response; Signal transduction; Taiwan; United States > US; China; Shenzhen China; Acinetobacter baumannii; ferroptosis; immune; NDM; pulmonary host response; mNGS

Background: For investigating the host response in Acinetobacter baumannii associated pneumonia, we analyzed the host genetic sequences obtained from metagenomic next-generation sequencing (mNGS). Methods: The samples for mNGS were bronchoalveolar lavage fluid (BALF) collected from the lungs of pati...