Synergic Crosstalk between Inflammation, Oxidative Stress, and Genomic Alterations in BCR–ABL-Negative Myeloproliferative Neoplasm

• Published in: Antioxidants Vol. 9; no. 11; p. 1037
• Main Authors: Allegra, Alessandro, Pioggia, Giovanni, Tonacci, Alessandro, Casciaro, Marco, Musolino, Caterina, Gangemi, Sebastiano
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 23.10.2020; MDPI
• Subjects: antioxidants; BCR-ABL protein; Bone marrow; chemical elements; Chemokines; Cytokines; Disease; Epidermal growth factor; essential thrombocythemia; Gene expression; genes; genomics; Health aspects; Hematopoietic stem cells; humans; Inflammation; Leukemia; Medical prognosis; Mutation; myelofibrosis; myeloproliferative neoplasms; neoplasms; Oxidative stress; Plasma; Polycythemia; Polycythemia vera; Proteins; Reactive oxygen species; Review; Stem cells; synthesis; therapeutics; transcriptomics; Tumors; Italy

Philadelphia-negative chronic myeloproliferative neoplasms (MPNs) have recently been revealed to be related to chronic inflammation, oxidative stress, and the accumulation of reactive oxygen species. It has been proposed that MPNs represent a human inflammation model for tumor advancement, in which...