Inhibitors of the Histone Methyltransferases EZH2/1 Induce a Potent Antiviral State and Suppress Infection by Diverse Viral Pathogens

• Published in: mBio Vol. 8; no. 4
• Main Authors: Arbuckle, Jesse H., Gardina, Paul J., Gordon, David N., Hickman, Heather D., Yewdell, Jonathan W., Pierson, Theodore C., Myers, Timothy G., Kristie, Thomas M.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 15.08.2017
• Subjects: antiviral; Antiviral Agents - pharmacology; chromatin; DNA Replication; Enhancer of Zeste Homolog 2 Protein - antagonists & inhibitors; Enzyme Inhibitors - pharmacology; Epigenetic Repression; epigenetics; Herpes Simplex - drug therapy; Herpes Simplex - immunology; Herpes Simplex - virology; herpesvirus; Herpesvirus 1, Human - drug effects; Herpesvirus 1, Human - genetics; Herpesvirus 1, Human - pathogenicity; Herpesvirus 1, Human - physiology; Humans; immune mechanisms; Immunity, Innate; innate immunity; Polycomb Repressive Complex 2 - antagonists & inhibitors; Virus Latency; Virus Replication - drug effects; Zika Virus - drug effects; Zika Virus - genetics; Zika Virus - pathogenicity; Zika Virus - physiology; Zika Virus Infection - immunology; Zika Virus Infection - virology; innate immunity; herpesvirus; immune mechanisms; antiviral; Zika virus; chromatin; epigenetics

Epigenetic regulation is based on a network of complexes that modulate the chromatin character and structure of the genome to impact gene expression, cell fate, and development. Thus, epigenetic modulators represent novel therapeutic targets used to treat a range of diseases, including malignancies....