Bcl-2 and Bcl-xL in Diabetes: Contributions to Endocrine Pancreas Viability and Function

• Published in: Biomedicines Vol. 13; no. 1; p. 223
• Main Authors: Perez-Serna, Atenea A., Guzman-Llorens, Daniel, Dos Santos, Reinaldo S., Marroqui, Laura
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.01.2025; MDPI
• Subjects: Amino acids; Apoptosis; Bcl-2; Bcl-2 protein; Bcl-x protein; Bcl-xL; Beta cells; Calcium (intracellular); Calcium (mitochondrial); Calcium homeostasis; Calcium metabolism; Cell cycle; Cell death; Cell survival; Cytochrome; Development and progression; Diabetes; Diabetes mellitus (insulin dependent); Diabetes mellitus (non-insulin dependent); Health aspects; Homeostasis; hormone secretion; Inhibitor of apoptosis proteins; Insulin; Leukemia; Localization; Lymphoma; Metabolic disorders; Metabolism; Pancreas; Pancreatic beta cells; pancreatic β-cells; Physiological aspects; Proteins; Review; Therapeutic targets; Type 1 diabetes; Type 2 diabetes; Viral infections; Spain; Bcl-2; pancreatic β-cells; apoptosis; Bcl-xL; hormone secretion; diabetes
• ISSN: 2227-9059; 2227-9059
• DOI: 10.3390/biomedicines13010223

Diabetes is a chronic metabolic disorder whose prevalence increases every year, affecting more than 530 million adults worldwide. Type 1 (T1D) and type 2 diabetes (T2D), the most common forms of diabetes, are characterized by the loss of functional pancreatic β-cells, mostly due to apoptosis. B-cell...