An mRNA vaccine encoding the SARS-CoV-2 Omicron XBB.1.5 receptor-binding domain protects mice from the JN.1 variant - Uraki, Ryuta; Kiso, Maki; Ito, Mutsumi; Yamayoshi, Seiya; Halfmann, Peter; Jain, Shilpi; Suthar, Mehul S.; Lopes, Tiago J.S.; Jounai, Nao; Miyaji, Kazuki; Takeshita, Fumihiko; Kawaoka, Yoshihiro (EBioMedicine, 2025)
Keywords: Advanced Basic Science; Animals; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; COVID-19 - immunology; COVID-19 - prevention & control; COVID-19 - virology; COVID-19 Vaccines - administration & dosage; COVID-19 Vaccines - genetics; COVID-19 Vaccines - immunology; Female; Humans; Immunization, Secondary; Internal Medicine; LNP-mRNA-RBD; Mice; Mice, Inbred BALB C; Mouse model; mRNA Vaccines - immunology; Omicron JN.1 variant; RNA, Messenger - genetics; RNA, Messenger - immunology; SARS-CoV-2; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; Vaccines, Synthetic - genetics; Vaccines, Synthetic - immunology; SARS-CoV-2; Mouse model; Omicron JN.1 variant; LNP-mRNA-RBD