Molecular Mechanisms of Long Noncoding RNAs

• Published in: Molecular cell Vol. 43; no. 6; pp. 904 - 914
• Main Authors: Wang, Kevin C., Chang, Howard Y.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 16.09.2011
• Subjects: Animals; Chromatin - metabolism; evolution; genes; Humans; Models, Genetic; non-coding RNA; prediction; Pseudogenes - physiology; RNA Polymerase II - physiology; RNA Stability; RNA, Untranslated - chemistry; RNA, Untranslated - metabolism; RNA, Untranslated - physiology; signal transduction; Telomerase - metabolism; Telomere - chemistry; Telomere - genetics; Transcription, Genetic

Long noncoding RNAs (lncRNAs) are an important class of pervasive genes involved in a variety of biological functions. Here we discuss the emerging archetypes of molecular functions that lncRNAs execute—as signals, decoys, guides, and scaffolds. For each archetype, examples from several disparate bi...