Design and statistical optimization of an effervescent floating drug delivery system of theophylline using response surface methodology

• Published in: Acta Pharmaceutica Vol. 66; no. 1; pp. 35 - 51
• Main Authors: Srikanth Meka, Venkata, Ee Li, Chew, Sheshala, Ravi
• Format: Journal Article Paper
• Language: English
• Published: Croatia De Gruyter Open 01.03.2016; De Gruyter Poland; Hrvatsko farmaceutsko društvo; Sciendo
• Subjects: Calorimetry, Differential Scanning - methods; Cellulose - analogs & derivatives; Cellulose - chemistry; central composite; Chemistry, Pharmaceutical - methods; Drug Carriers - chemistry; Drug Delivery Systems - methods; Drug Liberation; Excipients - chemistry; floating; gastroretentive; PEO N12K; Polyethylene Glycols - chemistry; Polymers - chemistry; Polymethacrylic Acids - chemistry; Polysaccharides, Bacterial - chemistry; Sodium Bicarbonate - chemistry; Solubility; Spectroscopy, Fourier Transform Infrared - methods; Tablets - chemistry; theophylline; Theophylline - chemistry

The aim of this research was to formulate effervescent floating drug delivery systems of theophylline using different release retarding polymers such as ethyl cellulose, Eudragit L100, xanthan gum and polyethylene oxide (PEO) N12K. Sodium bicarbonate was used as a gas generating agent. Direct compre...