IMVAMUNE®: modified vaccinia Ankara strain as an attenuated smallpox vaccine

• Published in: Expert review of vaccines Vol. 8; no. 1; pp. 13 - 24
• Main Authors: Kennedy, Jeffrey S, Greenberg, Richard N
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.01.2009; Taylor & Francis
• Subjects: adverse event; clinical trial; Clinical Trials as Topic; Humans; immunity; modified vaccinia Ankara; smallpox; Smallpox Vaccine - biosynthesis; Smallpox Vaccine - immunology; vaccine; Vaccine Profile; Vaccines, Attenuated - adverse effects; Vaccines, Attenuated - immunology; vaccinia

Smallpox vaccines based on replicating vaccinia virus are known to elicit rare yet serious adverse events, particularly in human populations with immune deficiency, atopic dermatitis and at the extremes of age. A vaccine that induces protective immune responses equivalent to first-generation smallpo...