Effect of Teriparatide on Bone Remodeling and Density in Premenopausal Idiopathic Osteoporosis: A Phase II Trial

• Published in: The journal of clinical endocrinology and metabolism Vol. 105; no. 10; pp. e3540 - e3556
• Main Authors: Cohen, Adi, Shiau, Stephanie, Nair, Nandini, Recker, Robert R, Lappe, Joan M, Dempster, David W, Nickolas, Thomas L, Zhou, Hua, Agarwal, Sanchita, Kamanda-Kosseh, Mafo, Bucovsky, Mariana, Williams, John M, McMahon, Donald J, Stubby, Julie, Shane, Elizabeth
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.10.2020
• Subjects: Absorptiometry, Photon; Adult; Biopsy; Bone Density - drug effects; Bone Density Conservation Agents - administration & dosage; Bone growth; Bone mineral density; Bone remodeling; Bone Remodeling - drug effects; Bone turnover; Drug therapy; Dual energy X-ray absorptiometry; Female; Health aspects; Humans; Hypercalcemia; Middle aged women; Online Only; Osteogenesis; Osteoporosis; Osteoporosis - drug therapy; Osteoporosis - metabolism; Parathyroid hormone; Premenopause - metabolism; Procollagen; Risk factors; Spine (lumbar); Teriparatide - administration & dosage; Treatment Outcome; United States; teriparatide; bone biopsy; premenopausal osteoporosis; bone turnover markers

Abstract Context Premenopausal women with idiopathic osteoporosis (IOP) have abnormal skeletal microarchitecture and variable tissue-level bone formation rate (BFR). Objectives Compare 6 months (M) of teriparatide versus placebo on areal bone mineral density (aBMD) by dual-energy x-ray absorptiometr...