Endothelial Function, Carotid–Femoral Stiffness, and Plasma Matrix Metalloproteinase-2 in Men With Bicuspid Aortic Valve and Dilated Aorta

• Published in: Journal of the American College of Cardiology Vol. 55; no. 7; pp. 660 - 668
• Main Authors: Tzemos, Nikolaos, Lyseggen, Erik, Silversides, Candice, Jamorski, Michal, Tong, Jeffrey H., Harvey, Paula, Floras, John, Siu, Samuel
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 16.02.2010; Elsevier; Elsevier Limited
• Subjects: Adult; Aorta - pathology; Aorta - physiopathology; aortic dilation; Aortic Valve - abnormalities; Aortic Valve - diagnostic imaging; Aortic Valve - physiopathology; bicuspid valve; Biological and medical sciences; Blood Flow Velocity - physiology; Brachial Artery - diagnostic imaging; Brachial Artery - physiology; Cardiology; Cardiology. Vascular system; Cardiovascular; Cardiovascular disease; Carotid Arteries - physiology; Case-Control Studies; Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava; Coronary vessels; Cross-Sectional Studies; Dilatation, Pathologic; Endocardial and cardiac valvular diseases; Endothelium, Vascular - physiopathology; Femoral Artery - physiology; flow-mediated vasodilation; Heart; Heart rate; Humans; Hyperemia - physiopathology; Hypertension; Internal Medicine; Male; Matrix Metalloproteinase 2 - blood; Matrix Metalloproteinase 9 - blood; Medical sciences; MMP-2; Nitroglycerin; Plasma; Pulsatile Flow - physiology; pulse wave velocity; Sinuses; Systole - physiology; Tissue Inhibitor of Metalloproteinase-1 - blood; Tissue Inhibitor of Metalloproteinase-2 - blood; Ultrasonography; Vasodilator Agents; GTN; NO; eNOS; aortic dilation; cf-PWV; CMR; flow-mediated vasodilation; LV; pulse wave velocity; MMP; MMP-2; BAV; RT3DE; FMD; bicuspid valve; TIMP; real-time 3-dimensional imaging; tissue inhibitor of matrix metalloproteinase; carotid–femoral pulse wave velocity; glyceryl nitrate; endothelial nitric oxide synthase; left ventricle/ventricular; nitric oxide; bicuspid aortic valve; matrix metalloproteinase; cardiac magnetic resonance; Human; Biological fluid; Femur; Enzyme; Metalloendopeptidases; Cardiovascular disease; Male; Endothelial function; Congenital disease; Gelatinase A; Blood plasma; Peptidases; Cardiac valvular disease; Carotid; Bicuspid aortic valve; Hydrolases; Aorta; Stiffness; Circulatory system; Cardiology

This study sought to examine the relationship between proximal aortic dilation and systemic vascular function in men with bicuspid aortic valve (BAV). Proximal aortic dilation in subjects with BAV is associated with structural and functional abnormalities in the ascending aorta. We studied 32 men (m...