Assessing the Impact of the Leader Peptide in Protease Inhibition by the Microviridin Family of RiPPs

• Published in: Biomedicines Vol. 12; no. 12; p. 2873
• Main Authors: Stafford, Jillian L., Montoya, Veronica K., Bierman, Jeffrey J., Walker, Mark C.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2024; MDPI
• Subjects: Biosynthesis; Cyanobacteria; E coli; Elastase; Enzymes; Escherichia coli; Genes; Hydrolysis; Kinases; microviridin; Natural products; Peptides; Plasmids; Post-translation; Protein sorting signals; Proteins; RiPP; Serine proteinase; Thrombin; California; United States; New Mexico; Massachusetts; United Kingdom > UK; England; United States > US; elastase; microviridin; RiPP

Background: Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a growing class of natural products biosynthesized from a genetically encoded precursor peptide. RiPPs have attracted attention for the ability to generate and screen libraries of these compounds for useful bi...