Hereditary hemochromatosis and transferrin receptor 2

• Published in: Biochimica et biophysica acta Vol. 1820; no. 3; pp. 256 - 263
• Main Authors: Chen, Juxing, Enns, Caroline A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2012
• Subjects: Anemia, Iron-Deficiency - genetics; Anemia, Iron-Deficiency - metabolism; Antimicrobial Cationic Peptides - metabolism; BMP; Cation Transport Proteins - metabolism; Erythropoiesis - genetics; Ferroportin; hematopoiesis; hemochromatosis; Hemochromatosis - genetics; Hemochromatosis - metabolism; Hemojuvelin; Hepcidin; Hepcidins; HFE; homeostasis; Humans; intestinal mucosa; Intestinal Mucosa - metabolism; Ion Transport; iron; Iron - metabolism; iron absorption; iron deficiency anemia; liver; Liver - metabolism; macrophages; Macrophages - metabolism; mutation; nutrients; Receptors, Transferrin - genetics; Receptors, Transferrin - metabolism; TfR2; transferrin; transport proteins; Ferroportin; Hemojuvelin; BMP; TfR2; Hepcidin; HFE

Multicellular organisms regulate the uptake of calories, trace elements, and other nutrients by complex feedback mechanisms. In the case of iron, the body senses internal iron stores, iron requirements for hematopoiesis, and inflammatory status, and regulates iron uptake by modulating the uptake of...